The white matter is a pro-differentiative niche for glioblastoma

Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligodendrocyte-like fate in a process that mimics myelin...

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Autores principales:	Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae
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spelling	oai:doaj.org-article:1dfd4c8671124520ac4d6ba779864aae2021-12-02T18:02:46ZThe white matter is a pro-differentiative niche for glioblastoma10.1038/s41467-021-22225-w2041-1723https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22225-whttps://doaj.org/toc/2041-1723Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligodendrocyte-like fate in a process that mimics myelin repair and results in tumour suppressionLucy J. BrooksMelanie P. ClementsJemima J. BurdenDaniela KocherLuca RichardsSara Castro DevesaLeila ZakkaMegan WoodberryMichael EllisZane JaunmuktaneSebastian BrandnerGillian MorrisonSteven M. PollardPeter B. DirksSamuel MargueratSimona ParrinelloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucy J. Brooks Melanie P. Clements Jemima J. Burden Daniela Kocher Luca Richards Sara Castro Devesa Leila Zakka Megan Woodberry Michael Ellis Zane Jaunmuktane Sebastian Brandner Gillian Morrison Steven M. Pollard Peter B. Dirks Samuel Marguerat Simona Parrinello The white matter is a pro-differentiative niche for glioblastoma
description	Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligodendrocyte-like fate in a process that mimics myelin repair and results in tumour suppression
format	article
author	Lucy J. Brooks Melanie P. Clements Jemima J. Burden Daniela Kocher Luca Richards Sara Castro Devesa Leila Zakka Megan Woodberry Michael Ellis Zane Jaunmuktane Sebastian Brandner Gillian Morrison Steven M. Pollard Peter B. Dirks Samuel Marguerat Simona Parrinello
author_facet	Lucy J. Brooks Melanie P. Clements Jemima J. Burden Daniela Kocher Luca Richards Sara Castro Devesa Leila Zakka Megan Woodberry Michael Ellis Zane Jaunmuktane Sebastian Brandner Gillian Morrison Steven M. Pollard Peter B. Dirks Samuel Marguerat Simona Parrinello
author_sort	Lucy J. Brooks
title	The white matter is a pro-differentiative niche for glioblastoma
title_short	The white matter is a pro-differentiative niche for glioblastoma
title_full	The white matter is a pro-differentiative niche for glioblastoma
title_fullStr	The white matter is a pro-differentiative niche for glioblastoma
title_full_unstemmed	The white matter is a pro-differentiative niche for glioblastoma
title_sort	white matter is a pro-differentiative niche for glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae
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The white matter is a pro-differentiative niche for glioblastoma

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