Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy

Abstract The factors associated with chronic opioid therapy (COT) in patients with HIV is understudied. Using Medicaid data (2002–2009), this retrospective cohort study examines COT in beneficiaries with HIV who initiated standard combination anti-retroviral therapy (cART). We used generalized estim...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	GYeon Oh, Emily S. Brouwer, Erin L. Abner, David W. Fardo, Patricia R. Freeman, Chris Delcher, Daniela C. Moga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1dffd6870a4b4650b0f7b795bb0e5705
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1dffd6870a4b4650b0f7b795bb0e5705
record_format	dspace
spelling	oai:doaj.org-article:1dffd6870a4b4650b0f7b795bb0e57052021-12-02T18:47:10ZPredictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy10.1038/s41598-021-94690-82045-2322https://doaj.org/article/1dffd6870a4b4650b0f7b795bb0e57052021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94690-8https://doaj.org/toc/2045-2322Abstract The factors associated with chronic opioid therapy (COT) in patients with HIV is understudied. Using Medicaid data (2002–2009), this retrospective cohort study examines COT in beneficiaries with HIV who initiated standard combination anti-retroviral therapy (cART). We used generalized estimating equations on logistic regression models with backward selection to identify significant predictors of COT initiation. COT was initiated among 1014 out of 9615 beneficiaries with HIV (male: 10.4%; female: 10.7%). Those with older age, any malignancy, Hepatitis C infection, back pain, arthritis, neuropathy pain, substance use disorder, polypharmacy, (use of) benzodiazepines, gabapentinoids, antidepressants, and prior opioid therapies were positively associated with COT. In sex-stratified analyses, multiple predictors were shared between male and female beneficiaries; however, chronic obstructive pulmonary disease, liver disease, any malignancy, and antipsychotic therapy were unique to female beneficiaries. Comorbidities and polypharmacy were important predictors of COT in Medicaid beneficiaries with HIV who initiated cART.GYeon OhEmily S. BrouwerErin L. AbnerDavid W. FardoPatricia R. FreemanChris DelcherDaniela C. MogaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q GYeon Oh Emily S. Brouwer Erin L. Abner David W. Fardo Patricia R. Freeman Chris Delcher Daniela C. Moga Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy
description	Abstract The factors associated with chronic opioid therapy (COT) in patients with HIV is understudied. Using Medicaid data (2002–2009), this retrospective cohort study examines COT in beneficiaries with HIV who initiated standard combination anti-retroviral therapy (cART). We used generalized estimating equations on logistic regression models with backward selection to identify significant predictors of COT initiation. COT was initiated among 1014 out of 9615 beneficiaries with HIV (male: 10.4%; female: 10.7%). Those with older age, any malignancy, Hepatitis C infection, back pain, arthritis, neuropathy pain, substance use disorder, polypharmacy, (use of) benzodiazepines, gabapentinoids, antidepressants, and prior opioid therapies were positively associated with COT. In sex-stratified analyses, multiple predictors were shared between male and female beneficiaries; however, chronic obstructive pulmonary disease, liver disease, any malignancy, and antipsychotic therapy were unique to female beneficiaries. Comorbidities and polypharmacy were important predictors of COT in Medicaid beneficiaries with HIV who initiated cART.
format	article
author	GYeon Oh Emily S. Brouwer Erin L. Abner David W. Fardo Patricia R. Freeman Chris Delcher Daniela C. Moga
author_facet	GYeon Oh Emily S. Brouwer Erin L. Abner David W. Fardo Patricia R. Freeman Chris Delcher Daniela C. Moga
author_sort	GYeon Oh
title	Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy
title_short	Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy
title_full	Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy
title_fullStr	Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy
title_full_unstemmed	Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy
title_sort	predictors of chronic opioid therapy in medicaid beneficiaries with hiv who initiated antiretroviral therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1dffd6870a4b4650b0f7b795bb0e5705
work_keys_str_mv	AT gyeonoh predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy AT emilysbrouwer predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy AT erinlabner predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy AT davidwfardo predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy AT patriciarfreeman predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy AT chrisdelcher predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy AT danielacmoga predictorsofchronicopioidtherapyinmedicaidbeneficiarieswithhivwhoinitiatedantiretroviraltherapy
_version_	1718377608273461248

Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy

Ejemplares similares