LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously undescribed genome integrity mechanism.

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Autores principales:	Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e006c13ac23401faf2de36c69fca25c
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spelling	oai:doaj.org-article:1e006c13ac23401faf2de36c69fca25c2021-12-02T15:34:15ZLEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis10.1038/s41467-018-03135-w2041-1723https://doaj.org/article/1e006c13ac23401faf2de36c69fca25c2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03135-whttps://doaj.org/toc/2041-1723Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously undescribed genome integrity mechanism.Ye HongRemi SonnevilleBin WangViktor ScheidtBettina MeierAlexander WoglarSarah DemetriouKarim LabibVerena JantschAnton GartnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ye Hong Remi Sonneville Bin Wang Viktor Scheidt Bettina Meier Alexander Woglar Sarah Demetriou Karim Labib Verena Jantsch Anton Gartner LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
description	Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously undescribed genome integrity mechanism.
format	article
author	Ye Hong Remi Sonneville Bin Wang Viktor Scheidt Bettina Meier Alexander Woglar Sarah Demetriou Karim Labib Verena Jantsch Anton Gartner
author_facet	Ye Hong Remi Sonneville Bin Wang Viktor Scheidt Bettina Meier Alexander Woglar Sarah Demetriou Karim Labib Verena Jantsch Anton Gartner
author_sort	Ye Hong
title	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_short	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_full	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_fullStr	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_full_unstemmed	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_sort	lem-3 is a midbody-tethered dna nuclease that resolves chromatin bridges during late mitosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1e006c13ac23401faf2de36c69fca25c
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LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

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