Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma

Abstract Circular RNAs (circRNAs) represent potential biomarkers because of their highly stable structure and robust expression pattern in clinical samples. The aim of this study was to evaluate the expression of a recently identified circRNA, hsa_circ_0005986; determine its clinical significance; a...

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Autores principales:	Gyeonghwa Kim, Ja Ryung Han, Soo Young Park, Won Young Tak, Young-Oh Kweon, Yu Rim Lee, Young Seok Han, Jung Gil Park, Min Kyu Kang, Hye Won Lee, Won Kee Lee, Deokhoon Kim, Se Young Jang, Keun Hur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e0193e6150d4d6f95afc5634489bdfb
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spelling	oai:doaj.org-article:1e0193e6150d4d6f95afc5634489bdfb2021-12-02T16:17:21ZCircular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma10.1038/s41598-021-94074-y2045-2322https://doaj.org/article/1e0193e6150d4d6f95afc5634489bdfb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94074-yhttps://doaj.org/toc/2045-2322Abstract Circular RNAs (circRNAs) represent potential biomarkers because of their highly stable structure and robust expression pattern in clinical samples. The aim of this study was to evaluate the expression of a recently identified circRNA, hsa_circ_0005986; determine its clinical significance; and evaluate its potential as a biomarker of hepatocellular carcinoma (HCC). We evaluated hsa_circ_0005986 expression in 123 HCC tissue samples, its clinical significance, and its association with patients’ clinicopathological characteristics and survival. Hsa_circ_0005986 expression was downregulated in HCC tissues. Low hsa_circ_0005986 expression was more common in tumors larger than 5 cm [odds ratio (OR), 3.19; 95% confidence interval (CI), 1.51–6.76; p = 0.002], advanced TNM stage (III/IV; OR, 2.39; 95% CI, 1.16–4.95; p = 0.018), and higher BCLC stage (B/C; OR, 2.71; 95% CI, 1.30–5.65; p = 0.007). High hsa_circ_0005986 expression was associated with improved survival and was an independent prognostic factor for overall [hazard ratio (HR), 0.572; 95% CI, 0.339–0.966; p = 0.037] and progression-free (HR, 0.573; 95% CI, 0.362–0.906; p = 0.017) survival. Moreover, the circRNA–miRNA–mRNA network was constructed using RNA-seq/miRNA-seq data and clinical information from TCGA-LIHC dataset. Our findings indicate a promising role for hsa_circ_0005986 as a prognostic biomarker in patients with HCC.Gyeonghwa KimJa Ryung HanSoo Young ParkWon Young TakYoung-Oh KweonYu Rim LeeYoung Seok HanJung Gil ParkMin Kyu KangHye Won LeeWon Kee LeeDeokhoon KimSe Young JangKeun HurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gyeonghwa Kim Ja Ryung Han Soo Young Park Won Young Tak Young-Oh Kweon Yu Rim Lee Young Seok Han Jung Gil Park Min Kyu Kang Hye Won Lee Won Kee Lee Deokhoon Kim Se Young Jang Keun Hur Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
description	Abstract Circular RNAs (circRNAs) represent potential biomarkers because of their highly stable structure and robust expression pattern in clinical samples. The aim of this study was to evaluate the expression of a recently identified circRNA, hsa_circ_0005986; determine its clinical significance; and evaluate its potential as a biomarker of hepatocellular carcinoma (HCC). We evaluated hsa_circ_0005986 expression in 123 HCC tissue samples, its clinical significance, and its association with patients’ clinicopathological characteristics and survival. Hsa_circ_0005986 expression was downregulated in HCC tissues. Low hsa_circ_0005986 expression was more common in tumors larger than 5 cm [odds ratio (OR), 3.19; 95% confidence interval (CI), 1.51–6.76; p = 0.002], advanced TNM stage (III/IV; OR, 2.39; 95% CI, 1.16–4.95; p = 0.018), and higher BCLC stage (B/C; OR, 2.71; 95% CI, 1.30–5.65; p = 0.007). High hsa_circ_0005986 expression was associated with improved survival and was an independent prognostic factor for overall [hazard ratio (HR), 0.572; 95% CI, 0.339–0.966; p = 0.037] and progression-free (HR, 0.573; 95% CI, 0.362–0.906; p = 0.017) survival. Moreover, the circRNA–miRNA–mRNA network was constructed using RNA-seq/miRNA-seq data and clinical information from TCGA-LIHC dataset. Our findings indicate a promising role for hsa_circ_0005986 as a prognostic biomarker in patients with HCC.
format	article
author	Gyeonghwa Kim Ja Ryung Han Soo Young Park Won Young Tak Young-Oh Kweon Yu Rim Lee Young Seok Han Jung Gil Park Min Kyu Kang Hye Won Lee Won Kee Lee Deokhoon Kim Se Young Jang Keun Hur
author_facet	Gyeonghwa Kim Ja Ryung Han Soo Young Park Won Young Tak Young-Oh Kweon Yu Rim Lee Young Seok Han Jung Gil Park Min Kyu Kang Hye Won Lee Won Kee Lee Deokhoon Kim Se Young Jang Keun Hur
author_sort	Gyeonghwa Kim
title	Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
title_short	Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
title_full	Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
title_fullStr	Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
title_full_unstemmed	Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
title_sort	circular noncoding rna hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1e0193e6150d4d6f95afc5634489bdfb
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Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma

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