The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al. show that the autophagy receptor p62/SQSTM1 is required for hormetic benefits and p62/SQSTM1 overexpression is sufficient to extend C. elegans li...

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Autores principales:	Caroline Kumsta, Jessica T. Chang, Reina Lee, Ee Phie Tan, Yongzhi Yang, Rute Loureiro, Elizabeth H. Choy, Shaun H. Y. Lim, Isabel Saez, Alexander Springhorn, Thorsten Hoppe, David Vilchez, Malene Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e02eb157af547f08c179b3732ae4d95
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spelling	oai:doaj.org-article:1e02eb157af547f08c179b3732ae4d952021-12-02T17:02:16ZThe autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy10.1038/s41467-019-13540-42041-1723https://doaj.org/article/1e02eb157af547f08c179b3732ae4d952019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13540-4https://doaj.org/toc/2041-1723While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al. show that the autophagy receptor p62/SQSTM1 is required for hormetic benefits and p62/SQSTM1 overexpression is sufficient to extend C. elegans lifespan and improve proteostasis.Caroline KumstaJessica T. ChangReina LeeEe Phie TanYongzhi YangRute LoureiroElizabeth H. ChoyShaun H. Y. LimIsabel SaezAlexander SpringhornThorsten HoppeDavid VilchezMalene HansenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline Kumsta Jessica T. Chang Reina Lee Ee Phie Tan Yongzhi Yang Rute Loureiro Elizabeth H. Choy Shaun H. Y. Lim Isabel Saez Alexander Springhorn Thorsten Hoppe David Vilchez Malene Hansen The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
description	While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al. show that the autophagy receptor p62/SQSTM1 is required for hormetic benefits and p62/SQSTM1 overexpression is sufficient to extend C. elegans lifespan and improve proteostasis.
format	article
author	Caroline Kumsta Jessica T. Chang Reina Lee Ee Phie Tan Yongzhi Yang Rute Loureiro Elizabeth H. Choy Shaun H. Y. Lim Isabel Saez Alexander Springhorn Thorsten Hoppe David Vilchez Malene Hansen
author_facet	Caroline Kumsta Jessica T. Chang Reina Lee Ee Phie Tan Yongzhi Yang Rute Loureiro Elizabeth H. Choy Shaun H. Y. Lim Isabel Saez Alexander Springhorn Thorsten Hoppe David Vilchez Malene Hansen
author_sort	Caroline Kumsta
title	The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
title_short	The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
title_full	The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
title_fullStr	The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
title_full_unstemmed	The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
title_sort	autophagy receptor p62/sqst-1 promotes proteostasis and longevity in c. elegans by inducing autophagy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1e02eb157af547f08c179b3732ae4d95
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The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

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