Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

Fibro-adipogenic progenitors (FAPs) form part of interstitial muscle connective tissue (MCT) in adults but the origin of this non-myogenic lineage is unclear. Here, the authors show that Odd skipped related 1 (Osr1) in mice marks embryonic MCT, giving rise to FAPs, and loss of Osr1 in the limb cause...

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Autores principales:	Pedro Vallecillo-García, Mickael Orgeur, Sophie vom Hofe-Schneider, Jürgen Stumm, Verena Kappert, Daniel M. Ibrahim, Stefan T. Börno, Shinichiro Hayashi, Frédéric Relaix, Katrin Hildebrandt, Gerhard Sengle, Manuel Koch, Bernd Timmermann, Giovanna Marazzi, David A. Sassoon, Delphine Duprez, Sigmar Stricker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e034f7aaeb14e40b5bb3d020e082645
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spelling	oai:doaj.org-article:1e034f7aaeb14e40b5bb3d020e0826452021-12-02T14:41:57ZOdd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development10.1038/s41467-017-01120-32041-1723https://doaj.org/article/1e034f7aaeb14e40b5bb3d020e0826452017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01120-3https://doaj.org/toc/2041-1723Fibro-adipogenic progenitors (FAPs) form part of interstitial muscle connective tissue (MCT) in adults but the origin of this non-myogenic lineage is unclear. Here, the authors show that Odd skipped related 1 (Osr1) in mice marks embryonic MCT, giving rise to FAPs, and loss of Osr1 in the limb causes muscle defects.Pedro Vallecillo-GarcíaMickael OrgeurSophie vom Hofe-SchneiderJürgen StummVerena KappertDaniel M. IbrahimStefan T. BörnoShinichiro HayashiFrédéric RelaixKatrin HildebrandtGerhard SengleManuel KochBernd TimmermannGiovanna MarazziDavid A. SassoonDelphine DuprezSigmar StrickerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pedro Vallecillo-García Mickael Orgeur Sophie vom Hofe-Schneider Jürgen Stumm Verena Kappert Daniel M. Ibrahim Stefan T. Börno Shinichiro Hayashi Frédéric Relaix Katrin Hildebrandt Gerhard Sengle Manuel Koch Bernd Timmermann Giovanna Marazzi David A. Sassoon Delphine Duprez Sigmar Stricker Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
description	Fibro-adipogenic progenitors (FAPs) form part of interstitial muscle connective tissue (MCT) in adults but the origin of this non-myogenic lineage is unclear. Here, the authors show that Odd skipped related 1 (Osr1) in mice marks embryonic MCT, giving rise to FAPs, and loss of Osr1 in the limb causes muscle defects.
format	article
author	Pedro Vallecillo-García Mickael Orgeur Sophie vom Hofe-Schneider Jürgen Stumm Verena Kappert Daniel M. Ibrahim Stefan T. Börno Shinichiro Hayashi Frédéric Relaix Katrin Hildebrandt Gerhard Sengle Manuel Koch Bernd Timmermann Giovanna Marazzi David A. Sassoon Delphine Duprez Sigmar Stricker
author_facet	Pedro Vallecillo-García Mickael Orgeur Sophie vom Hofe-Schneider Jürgen Stumm Verena Kappert Daniel M. Ibrahim Stefan T. Börno Shinichiro Hayashi Frédéric Relaix Katrin Hildebrandt Gerhard Sengle Manuel Koch Bernd Timmermann Giovanna Marazzi David A. Sassoon Delphine Duprez Sigmar Stricker
author_sort	Pedro Vallecillo-García
title	Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
title_short	Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
title_full	Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
title_fullStr	Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
title_full_unstemmed	Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
title_sort	odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1e034f7aaeb14e40b5bb3d020e082645
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Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

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