Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Altaf A Kondkar,1 Taif A Azad,1 Faisal A Almobarak,1 Hatem Kalantan,1 Saleh A Al-Obeidan,1 Khaled K Abu-Amero1,2 1Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology and Visual Sciences, University of Il...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kondkar AA, Azad TA, Almobarak FA, Kalantan H, Al-Obeidan SA, Abu-Amero KK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	glaucoma inflammation oxidative stress pseudoexfoliation TNF-α Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1e03b0016d3546fb82b6a59697cd5742
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e03b0016d3546fb82b6a59697cd5742
record_format	dspace
spelling	oai:doaj.org-article:1e03b0016d3546fb82b6a59697cd57422021-12-02T02:34:22ZElevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma1177-5483https://doaj.org/article/1e03b0016d3546fb82b6a59697cd57422018-01-01T00:00:00Zhttps://www.dovepress.com/elevated-levels-of-plasma-tumor-necrosis-factor-alpha-in-patients-with-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Altaf A Kondkar,1 Taif A Azad,1 Faisal A Almobarak,1 Hatem Kalantan,1 Saleh A Al-Obeidan,1 Khaled K Abu-Amero1,2 1Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA Background: Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine, which plays a role in glaucomatous neurodegeneration. Based on the plausible role of inflammation in the pathogenesis of pseudoexfoliation glaucoma (PEG), we investigated whether there is any relationship between the levels of plasma TNF-α and PEG or any of its clinical indices in comparison to normal controls.Methods: The study was designed as a retrospective analysis. Plasma samples from 49 PEG patients and 88 non-glaucomatous controls were evaluated for TNF-α levels using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on a biochemical/ELISA analyzer.Results: The two study groups were similar in age, sex and systemic disease distribution. The mean TNF-α concentration was significantly higher in the PEG patients (5.54±4.58 pg/mL) than in the control subjects (0.93±1.49 pg/mL; 95% confidence interval [CI] =3.50–5.72; p=0.000). The overall dose–response trend was significant (χ2=57.07, df=2; p=0.000). A moderate positive and significant correlation was seen between TNF-α level and cup/disc ratio, an important clinical index for PEG. Besides, binary logistic regression analysis showed that the risk of PEG was most significantly affected by TNF-α level as compared to no association with age and sex. In receiver operating characteristic analysis, the area under the curve was 0.777 (95% CI =0.682–0.872) and statistically significant (p=0.000).Conclusion: Elevated systemic levels of inflammatory marker, TNF-α, are associated with PEG and may possibly serve as a biomarker for undiagnosed early glaucoma and/or as a marker for disease progression. Keywords: glaucoma, inflammation, oxidative stress, pseudoexfoliation, TNF-αKondkar AAAzad TAAlmobarak FAKalantan HAl-Obeidan SAAbu-Amero KKDove Medical Pressarticleglaucomainflammationoxidative stresspseudoexfoliationTNF-αOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 153-159 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma inflammation oxidative stress pseudoexfoliation TNF-α Ophthalmology RE1-994
spellingShingle	glaucoma inflammation oxidative stress pseudoexfoliation TNF-α Ophthalmology RE1-994 Kondkar AA Azad TA Almobarak FA Kalantan H Al-Obeidan SA Abu-Amero KK Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
description	Altaf A Kondkar,1 Taif A Azad,1 Faisal A Almobarak,1 Hatem Kalantan,1 Saleh A Al-Obeidan,1 Khaled K Abu-Amero1,2 1Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA Background: Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine, which plays a role in glaucomatous neurodegeneration. Based on the plausible role of inflammation in the pathogenesis of pseudoexfoliation glaucoma (PEG), we investigated whether there is any relationship between the levels of plasma TNF-α and PEG or any of its clinical indices in comparison to normal controls.Methods: The study was designed as a retrospective analysis. Plasma samples from 49 PEG patients and 88 non-glaucomatous controls were evaluated for TNF-α levels using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on a biochemical/ELISA analyzer.Results: The two study groups were similar in age, sex and systemic disease distribution. The mean TNF-α concentration was significantly higher in the PEG patients (5.54±4.58 pg/mL) than in the control subjects (0.93±1.49 pg/mL; 95% confidence interval [CI] =3.50–5.72; p=0.000). The overall dose–response trend was significant (χ2=57.07, df=2; p=0.000). A moderate positive and significant correlation was seen between TNF-α level and cup/disc ratio, an important clinical index for PEG. Besides, binary logistic regression analysis showed that the risk of PEG was most significantly affected by TNF-α level as compared to no association with age and sex. In receiver operating characteristic analysis, the area under the curve was 0.777 (95% CI =0.682–0.872) and statistically significant (p=0.000).Conclusion: Elevated systemic levels of inflammatory marker, TNF-α, are associated with PEG and may possibly serve as a biomarker for undiagnosed early glaucoma and/or as a marker for disease progression. Keywords: glaucoma, inflammation, oxidative stress, pseudoexfoliation, TNF-α
format	article
author	Kondkar AA Azad TA Almobarak FA Kalantan H Al-Obeidan SA Abu-Amero KK
author_facet	Kondkar AA Azad TA Almobarak FA Kalantan H Al-Obeidan SA Abu-Amero KK
author_sort	Kondkar AA
title	Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
title_short	Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
title_full	Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
title_fullStr	Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
title_full_unstemmed	Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
title_sort	elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1e03b0016d3546fb82b6a59697cd5742
work_keys_str_mv	AT kondkaraa elevatedlevelsofplasmatumornecrosisfactoralphainpatientswithpseudoexfoliationglaucoma AT azadta elevatedlevelsofplasmatumornecrosisfactoralphainpatientswithpseudoexfoliationglaucoma AT almobarakfa elevatedlevelsofplasmatumornecrosisfactoralphainpatientswithpseudoexfoliationglaucoma AT kalantanh elevatedlevelsofplasmatumornecrosisfactoralphainpatientswithpseudoexfoliationglaucoma AT alobeidansa elevatedlevelsofplasmatumornecrosisfactoralphainpatientswithpseudoexfoliationglaucoma AT abuamerokk elevatedlevelsofplasmatumornecrosisfactoralphainpatientswithpseudoexfoliationglaucoma
_version_	1718402332556787712

Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma

Ejemplares similares