Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia

Background: Follicle-stimulating hormone (FSH) is a pivotal hormone for male fertility, and its action on gonads is exerted by FSH receptors (FSHRs). Objectives: To examine whether the presence of FSHR gene single nucleotide polymorphisms (SNPs), G919A and A2039G, involved in non-obstructive azoo...

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Autores principales:	Abdul-Rahim A. Ali, Omar F. Abdul-Rasheed, Ula M. Alkawaz
Formato:	article
Lenguaje:	EN
Publicado:	College of Medicine, Al-Nahrain University 2021
Materias:	follicle-stimulating hormone receptor male infertility non-obstructive azoospermia rs6165 rs6166 single nucleotide polymorphism Biology (General) QH301-705.5 Microbiology QR1-502 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Biotechnology TP248.13-248.65 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/1e067f0c07a5472292370fb3c68cdbfb
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spelling	oai:doaj.org-article:1e067f0c07a5472292370fb3c68cdbfb2021-11-06T09:38:10ZFollicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia10.47419/bjbabs.v2i04.762706-9915https://doaj.org/article/1e067f0c07a5472292370fb3c68cdbfb2021-11-01T00:00:00Zhttps://bjbabs.org/index.php/bjbabs/article/view/76/46https://doaj.org/toc/2706-9915Background: Follicle-stimulating hormone (FSH) is a pivotal hormone for male fertility, and its action on gonads is exerted by FSH receptors (FSHRs). Objectives: To examine whether the presence of FSHR gene single nucleotide polymorphisms (SNPs), G919A and A2039G, involved in non-obstructive azoospermia (NOA) in Iraqi infertile men. Methods: Two common SNPs, A919G and A2039G, in the FSHR gene were analyzed in 104 subjects (70 infertile patients with NOO: 33 NOA patients were not receiving treatment and 37 were on infertility treatment, and 34 normozoospermic fertile men as controls). Results: The results revealed that the homozygous wild genotype (AA) of rs6165 FSHR gene SNP was more abundant than (AG) and (GG) genotypes in both groups of infertile NOA patients with a frequency of 49% in those who untreated, 81% in patients undergoing treatment and in the control group 41%. Whereas, the highest percentage of heterozygous genotype (AG) in the fertile control group was 41% when compared to NOApatients with a genotype frequency of 24% (for those who untreated) and 11% (for patients on treatment), respectively; with (A) allele frequency of 86% and the observed frequency of (G) allele was only 14% in the patients’ group as compared to that of controls that were (65 %) and (35 %), respectively. The rs6166 genotyping revealed that the homozygous wild genotype (GG) of FSHR gene was more abundant than (AG) and (AA) genotypes in NOA patients receiving infertility treatment with a frequency of (68%), in NOA patients who didn’t receive treatment 49%, while the lowest frequency was detected in the healthy fertile control group (47%). Conclusions: These results support the evidence that rs6165 and rs6166, FSHR SNPs, might be involved in the pathogenesis and protection against NOA, respectively.Abdul-Rahim A. AliOmar F. Abdul-RasheedUla M. AlkawazCollege of Medicine, Al-Nahrain Universityarticlefollicle-stimulating hormone receptormale infertilitynon-obstructive azoospermiars6165rs6166single nucleotide polymorphismBiology (General)QH301-705.5MicrobiologyQR1-502Diseases of the endocrine glands. Clinical endocrinologyRC648-665BiotechnologyTP248.13-248.65BiochemistryQD415-436ENBaghdad Journal of Biochemistry and Applied Biological Sciences, Vol 2, Iss 04, Pp 187-202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	follicle-stimulating hormone receptor male infertility non-obstructive azoospermia rs6165 rs6166 single nucleotide polymorphism Biology (General) QH301-705.5 Microbiology QR1-502 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Biotechnology TP248.13-248.65 Biochemistry QD415-436
spellingShingle	follicle-stimulating hormone receptor male infertility non-obstructive azoospermia rs6165 rs6166 single nucleotide polymorphism Biology (General) QH301-705.5 Microbiology QR1-502 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Biotechnology TP248.13-248.65 Biochemistry QD415-436 Abdul-Rahim A. Ali Omar F. Abdul-Rasheed Ula M. Alkawaz Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia
description	Background: Follicle-stimulating hormone (FSH) is a pivotal hormone for male fertility, and its action on gonads is exerted by FSH receptors (FSHRs). Objectives: To examine whether the presence of FSHR gene single nucleotide polymorphisms (SNPs), G919A and A2039G, involved in non-obstructive azoospermia (NOA) in Iraqi infertile men. Methods: Two common SNPs, A919G and A2039G, in the FSHR gene were analyzed in 104 subjects (70 infertile patients with NOO: 33 NOA patients were not receiving treatment and 37 were on infertility treatment, and 34 normozoospermic fertile men as controls). Results: The results revealed that the homozygous wild genotype (AA) of rs6165 FSHR gene SNP was more abundant than (AG) and (GG) genotypes in both groups of infertile NOA patients with a frequency of 49% in those who untreated, 81% in patients undergoing treatment and in the control group 41%. Whereas, the highest percentage of heterozygous genotype (AG) in the fertile control group was 41% when compared to NOApatients with a genotype frequency of 24% (for those who untreated) and 11% (for patients on treatment), respectively; with (A) allele frequency of 86% and the observed frequency of (G) allele was only 14% in the patients’ group as compared to that of controls that were (65 %) and (35 %), respectively. The rs6166 genotyping revealed that the homozygous wild genotype (GG) of FSHR gene was more abundant than (AG) and (AA) genotypes in NOA patients receiving infertility treatment with a frequency of (68%), in NOA patients who didn’t receive treatment 49%, while the lowest frequency was detected in the healthy fertile control group (47%). Conclusions: These results support the evidence that rs6165 and rs6166, FSHR SNPs, might be involved in the pathogenesis and protection against NOA, respectively.
format	article
author	Abdul-Rahim A. Ali Omar F. Abdul-Rasheed Ula M. Alkawaz
author_facet	Abdul-Rahim A. Ali Omar F. Abdul-Rasheed Ula M. Alkawaz
author_sort	Abdul-Rahim A. Ali
title	Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia
title_short	Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia
title_full	Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia
title_fullStr	Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia
title_full_unstemmed	Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia
title_sort	follicle-stimulating hormone (fsh) receptor gene polymorphisms in iraqi patients with non-obstructive azoospermia
publisher	College of Medicine, Al-Nahrain University
publishDate	2021
url	https://doaj.org/article/1e067f0c07a5472292370fb3c68cdbfb
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Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia

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