Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.

Objectives of this study were to evaluate glomerular filtration rate (GFR), renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC) administration. Eleven Beagle dogs ≥10 years old were treated with either hydrocortisone (HC group, n = 6) or placebo (control...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pascale M Y Smets, Hervé P Lefebvre, Luca Aresu, Siska Croubels, Hendrik Haers, Koen Piron, Evelyne Meyer, Sylvie Daminet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e07e82cac904489baa836ed3445de36
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e07e82cac904489baa836ed3445de36
record_format	dspace
spelling	oai:doaj.org-article:1e07e82cac904489baa836ed3445de362021-11-18T07:26:28ZRenal function and morphology in aged Beagle dogs before and after hydrocortisone administration.1932-620310.1371/journal.pone.0031702https://doaj.org/article/1e07e82cac904489baa836ed3445de362012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22393368/?tool=EBIhttps://doaj.org/toc/1932-6203Objectives of this study were to evaluate glomerular filtration rate (GFR), renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC) administration. Eleven Beagle dogs ≥10 years old were treated with either hydrocortisone (HC group, n = 6) or placebo (control group, n = 5). Urinary markers, GFR and kidney biopsies were evaluated before (T0), during (T16 wks) and after discontinuing HC administration (T24 wks). Results indicate that HC administration causes a significant increase in GFR. At all time points except T16 wks, proteinuria was higher in the control group than in the HC group, and there was no significant difference in urinary markers between groups. At T16 wks, proteinuria, urinary albumin-to-creatinine (c) ratio, immunoglobulin G/c and retinol-binding protein/c were higher compared to baseline in the HC group. At T0, rare to mild renal lesions were detected in all HC dogs and rare to moderate changes in all control dogs. Glomerulosclerosis progressed in both groups until T24 wks. Tubular atrophy was detected in three HC dogs at T16 wks and T24 wks, but also in five control dogs throughout the study. At every time point, five HC dogs and all control dogs had rare to moderate interstitial inflammation. Rare to mild interstitial fibrosis was found in up to three HC dogs at T16 wks and T24 wks, and severe fibrosis in one HC dog at T24 wks. Up to four control dogs had rare to mild fibrosis at all time points. These findings indicate that clinically healthy, aged Beagle dogs may have considerable renal lesions and proteinuria, which could have implications for experimental or toxicological studies. Additional research is needed to elucidate glucocorticoid effects on renal structure, but functional changes such as hyperfiltration and proteinuria warrant attention to kidney function of canine patients with Cushing's syndrome or receiving exogenous glucocorticoids.Pascale M Y SmetsHervé P LefebvreLuca AresuSiska CroubelsHendrik HaersKoen PironEvelyne MeyerSylvie DaminetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31702 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pascale M Y Smets Hervé P Lefebvre Luca Aresu Siska Croubels Hendrik Haers Koen Piron Evelyne Meyer Sylvie Daminet Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
description	Objectives of this study were to evaluate glomerular filtration rate (GFR), renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC) administration. Eleven Beagle dogs ≥10 years old were treated with either hydrocortisone (HC group, n = 6) or placebo (control group, n = 5). Urinary markers, GFR and kidney biopsies were evaluated before (T0), during (T16 wks) and after discontinuing HC administration (T24 wks). Results indicate that HC administration causes a significant increase in GFR. At all time points except T16 wks, proteinuria was higher in the control group than in the HC group, and there was no significant difference in urinary markers between groups. At T16 wks, proteinuria, urinary albumin-to-creatinine (c) ratio, immunoglobulin G/c and retinol-binding protein/c were higher compared to baseline in the HC group. At T0, rare to mild renal lesions were detected in all HC dogs and rare to moderate changes in all control dogs. Glomerulosclerosis progressed in both groups until T24 wks. Tubular atrophy was detected in three HC dogs at T16 wks and T24 wks, but also in five control dogs throughout the study. At every time point, five HC dogs and all control dogs had rare to moderate interstitial inflammation. Rare to mild interstitial fibrosis was found in up to three HC dogs at T16 wks and T24 wks, and severe fibrosis in one HC dog at T24 wks. Up to four control dogs had rare to mild fibrosis at all time points. These findings indicate that clinically healthy, aged Beagle dogs may have considerable renal lesions and proteinuria, which could have implications for experimental or toxicological studies. Additional research is needed to elucidate glucocorticoid effects on renal structure, but functional changes such as hyperfiltration and proteinuria warrant attention to kidney function of canine patients with Cushing's syndrome or receiving exogenous glucocorticoids.
format	article
author	Pascale M Y Smets Hervé P Lefebvre Luca Aresu Siska Croubels Hendrik Haers Koen Piron Evelyne Meyer Sylvie Daminet
author_facet	Pascale M Y Smets Hervé P Lefebvre Luca Aresu Siska Croubels Hendrik Haers Koen Piron Evelyne Meyer Sylvie Daminet
author_sort	Pascale M Y Smets
title	Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
title_short	Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
title_full	Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
title_fullStr	Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
title_full_unstemmed	Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.
title_sort	renal function and morphology in aged beagle dogs before and after hydrocortisone administration.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1e07e82cac904489baa836ed3445de36
work_keys_str_mv	AT pascalemysmets renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT herveplefebvre renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT lucaaresu renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT siskacroubels renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT hendrikhaers renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT koenpiron renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT evelynemeyer renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration AT sylviedaminet renalfunctionandmorphologyinagedbeagledogsbeforeandafterhydrocortisoneadministration
_version_	1718423460855676928

Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.

Ejemplares similares