Case report: acute liver failure induced by paracetamol toxicity

Introduction. Paracetamol is the most commonly used drug across Western Europe and North America. There is no such trend of using Paracetamol in the Republic of Moldova, thus overdose cases are extremely rare. The mechanisms leading to overdose episodes might induce hepatotoxicity. Clinical case. T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eugen TCACIUC, Mariana PODUREAN, Olga SCHIOPU, Aurel BATRINAC, Angela SELIVANOV, Dumitru COLOMAN
Formato:	article
Lenguaje:	EN FR RO RU
Publicado:	Asociatia de Biosiguranta si Biosecuritate 2021
Materias:	paracetamol overdose n-acetyl-cysteine hepatotoxicity acute liver failure Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e0d8fee4f0e4de69ceb67d12d28ee9c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e0d8fee4f0e4de69ceb67d12d28ee9c
record_format	dspace
spelling	oai:doaj.org-article:1e0d8fee4f0e4de69ceb67d12d28ee9c2021-12-02T18:15:23ZCase report: acute liver failure induced by paracetamol toxicity10.38045/ohrm.2021.1.082887-34582587-3466https://doaj.org/article/1e0d8fee4f0e4de69ceb67d12d28ee9c2021-01-01T00:00:00Zhttps://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/88/66https://doaj.org/toc/2887-3458https://doaj.org/toc/2587-3466Introduction. Paracetamol is the most commonly used drug across Western Europe and North America. There is no such trend of using Paracetamol in the Republic of Moldova, thus overdose cases are extremely rare. The mechanisms leading to overdose episodes might induce hepatotoxicity. Clinical case. This present article reports a case of acute liver failure induced by Paracetamol overdose. A 46-year-old man presented to the Medpark International Hospital. He was administered Paracetamol 1000 mg, approximately every 4 hours for 2 days, and 1000 mg twice a day for another 2 days, after an intense physical exertion, followed by muscle fever with myalgia and low-grade fever (37.4 °C) The reason for asking the medical care were pronounced fatigue, nausea, loss of appetite, night sweats, and frequent urination. Conclusion. Eventually, the case was successfully resolved due to N-acetyl-cysteine, administered according to the established treatment scheme, as well as the adjuvant therapy.Eugen TCACIUCMariana PODUREANOlga SCHIOPUAurel BATRINACAngela SELIVANOVDumitru COLOMANAsociatia de Biosiguranta si Biosecuritatearticleparacetamoloverdosen-acetyl-cysteinehepatotoxicityacute liver failureMedicineRScienceQENFRRORUOne Health & Risk Management, Vol 2, Iss 1, Pp 69-74 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR RO RU
topic	paracetamol overdose n-acetyl-cysteine hepatotoxicity acute liver failure Medicine R Science Q
spellingShingle	paracetamol overdose n-acetyl-cysteine hepatotoxicity acute liver failure Medicine R Science Q Eugen TCACIUC Mariana PODUREAN Olga SCHIOPU Aurel BATRINAC Angela SELIVANOV Dumitru COLOMAN Case report: acute liver failure induced by paracetamol toxicity
description	Introduction. Paracetamol is the most commonly used drug across Western Europe and North America. There is no such trend of using Paracetamol in the Republic of Moldova, thus overdose cases are extremely rare. The mechanisms leading to overdose episodes might induce hepatotoxicity. Clinical case. This present article reports a case of acute liver failure induced by Paracetamol overdose. A 46-year-old man presented to the Medpark International Hospital. He was administered Paracetamol 1000 mg, approximately every 4 hours for 2 days, and 1000 mg twice a day for another 2 days, after an intense physical exertion, followed by muscle fever with myalgia and low-grade fever (37.4 °C) The reason for asking the medical care were pronounced fatigue, nausea, loss of appetite, night sweats, and frequent urination. Conclusion. Eventually, the case was successfully resolved due to N-acetyl-cysteine, administered according to the established treatment scheme, as well as the adjuvant therapy.
format	article
author	Eugen TCACIUC Mariana PODUREAN Olga SCHIOPU Aurel BATRINAC Angela SELIVANOV Dumitru COLOMAN
author_facet	Eugen TCACIUC Mariana PODUREAN Olga SCHIOPU Aurel BATRINAC Angela SELIVANOV Dumitru COLOMAN
author_sort	Eugen TCACIUC
title	Case report: acute liver failure induced by paracetamol toxicity
title_short	Case report: acute liver failure induced by paracetamol toxicity
title_full	Case report: acute liver failure induced by paracetamol toxicity
title_fullStr	Case report: acute liver failure induced by paracetamol toxicity
title_full_unstemmed	Case report: acute liver failure induced by paracetamol toxicity
title_sort	case report: acute liver failure induced by paracetamol toxicity
publisher	Asociatia de Biosiguranta si Biosecuritate
publishDate	2021
url	https://doaj.org/article/1e0d8fee4f0e4de69ceb67d12d28ee9c
work_keys_str_mv	AT eugentcaciuc casereportacuteliverfailureinducedbyparacetamoltoxicity AT marianapodurean casereportacuteliverfailureinducedbyparacetamoltoxicity AT olgaschiopu casereportacuteliverfailureinducedbyparacetamoltoxicity AT aurelbatrinac casereportacuteliverfailureinducedbyparacetamoltoxicity AT angelaselivanov casereportacuteliverfailureinducedbyparacetamoltoxicity AT dumitrucoloman casereportacuteliverfailureinducedbyparacetamoltoxicity
_version_	1718378380029591552

Case report: acute liver failure induced by paracetamol toxicity

Ejemplares similares