Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells

Abstract Quercetin is one of the most abundant flavonoids, present in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Green tea is a widely consumed beverage, known for a potential source of free radical scavenging and anti-cancer...

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Autores principales:	Andrana Karla Calgarotto, Victor Maso, Gilberto Carlos Franchi Junior, Alexandre Eduardo Nowill, Paulo Latuf Filho, José Vassallo, Sara Teresinha Olalla Saad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e106ad23cdc4dcb8581d12a1d79fb60
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spelling	oai:doaj.org-article:1e106ad23cdc4dcb8581d12a1d79fb602021-12-02T15:08:43ZAntitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells10.1038/s41598-018-21516-52045-2322https://doaj.org/article/1e106ad23cdc4dcb8581d12a1d79fb602018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21516-5https://doaj.org/toc/2045-2322Abstract Quercetin is one of the most abundant flavonoids, present in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Green tea is a widely consumed beverage, known for a potential source of free radical scavenging and anti-cancer activities. Herein, we investigate the in vivo antitumor efficacy of quercetin and green tea in human leukemia. Human tumors were xenografted into NOD/SCID mice. Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein. Moreover, caspase-3 was activated to a greater extent after quercetin and green tea treatment. Quercetin and green tea also mediated G1 phase cell cycle arrest in HL-60 xenografts. Treatment with quercetin and green tea induced conversion of LC3-I to LC3-II as well as activation of autophagy proteins, suggesting that quercetin and green tea initiate the autophagic progression. We have provided evidence that quercetin and green tea induces signaling at the level of apoptosis, cell cycle and autophagy which converge to antigrowth effects in HL-60 xenograft mice suggesting that these compounds may be a compelling ally in cancer treatment.Andrana Karla CalgarottoVictor MasoGilberto Carlos Franchi JuniorAlexandre Eduardo NowillPaulo Latuf FilhoJosé VassalloSara Teresinha Olalla SaadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrana Karla Calgarotto Victor Maso Gilberto Carlos Franchi Junior Alexandre Eduardo Nowill Paulo Latuf Filho José Vassallo Sara Teresinha Olalla Saad Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells
description	Abstract Quercetin is one of the most abundant flavonoids, present in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Green tea is a widely consumed beverage, known for a potential source of free radical scavenging and anti-cancer activities. Herein, we investigate the in vivo antitumor efficacy of quercetin and green tea in human leukemia. Human tumors were xenografted into NOD/SCID mice. Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein. Moreover, caspase-3 was activated to a greater extent after quercetin and green tea treatment. Quercetin and green tea also mediated G1 phase cell cycle arrest in HL-60 xenografts. Treatment with quercetin and green tea induced conversion of LC3-I to LC3-II as well as activation of autophagy proteins, suggesting that quercetin and green tea initiate the autophagic progression. We have provided evidence that quercetin and green tea induces signaling at the level of apoptosis, cell cycle and autophagy which converge to antigrowth effects in HL-60 xenograft mice suggesting that these compounds may be a compelling ally in cancer treatment.
format	article
author	Andrana Karla Calgarotto Victor Maso Gilberto Carlos Franchi Junior Alexandre Eduardo Nowill Paulo Latuf Filho José Vassallo Sara Teresinha Olalla Saad
author_facet	Andrana Karla Calgarotto Victor Maso Gilberto Carlos Franchi Junior Alexandre Eduardo Nowill Paulo Latuf Filho José Vassallo Sara Teresinha Olalla Saad
author_sort	Andrana Karla Calgarotto
title	Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells
title_short	Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells
title_full	Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells
title_fullStr	Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells
title_full_unstemmed	Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells
title_sort	antitumor activities of quercetin and green tea in xenografts of human leukemia hl60 cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1e106ad23cdc4dcb8581d12a1d79fb60
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Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells

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