Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma
Manish K Thakur, Antoinette J Wozniak, Department of Oncology, Karmanos Cancer Center, Detroit, MI, USA Abstract: The treatment options for metastatic non-small-cell lung cancer (NSCLC) have expanded dramatically in the last 10 years with the discovery of newer drugs and targeted therapy. E...
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Dove Medical Press
2017
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oai:doaj.org-article:1e1088eece5141f0836f45d2480620202021-12-02T07:17:15ZSpotlight on necitumumab in the treatment of non-small-cell lung carcinoma1179-2728https://doaj.org/article/1e1088eece5141f0836f45d2480620202017-02-01T00:00:00Zhttps://www.dovepress.com/spotlight-on-necitumumab-in-the-treatment-of-non-small-cell-lung-carci-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Manish K Thakur, Antoinette J Wozniak, Department of Oncology, Karmanos Cancer Center, Detroit, MI, USA Abstract: The treatment options for metastatic non-small-cell lung cancer (NSCLC) have expanded dramatically in the last 10 years with the discovery of newer drugs and targeted therapy. Epidermal growth factor receptor (EGFR), when aberrantly activated, promotes cell growth and contributes in various ways to the malignant process. EGFR has become an important therapeutic target in a variety of malignancies. Small-molecule tyrosine kinase inhibitors (TKIs) of EGFR are being used to treat advanced NSCLC and are particularly effective in the presence of EGFR mutations. Monoclonal antibodies have also been developed that block the EGFR at the cell surface and work in conjunction with chemotherapy. Necitumumab is a second-generation fully human IgG1 monoclonal antibody that has shown promise in metastatic NSCLC. The benefit has mostly been restricted to squamous cell lung cancer in the frontline setting. Considering that the survival advantage for these patients was modest, there is a need to discover biomarkers that will predict which patients will likely have the best outcomes. This review focuses on the development and clinical trial experience with necitumumab in NSCLC. Keywords: lung cancer, squamous cell, necitumumab, EGFRThakur MKWozniak AJDove Medical Pressarticlelung cancernecitumumabsquamous cell lung cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 8, Pp 13-19 (2017) |
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DOAJ |
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lung cancer necitumumab squamous cell lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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lung cancer necitumumab squamous cell lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Thakur MK Wozniak AJ Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
description |
Manish K Thakur, Antoinette J Wozniak, Department of Oncology, Karmanos Cancer Center, Detroit, MI, USA Abstract: The treatment options for metastatic non-small-cell lung cancer (NSCLC) have expanded dramatically in the last 10 years with the discovery of newer drugs and targeted therapy. Epidermal growth factor receptor (EGFR), when aberrantly activated, promotes cell growth and contributes in various ways to the malignant process. EGFR has become an important therapeutic target in a variety of malignancies. Small-molecule tyrosine kinase inhibitors (TKIs) of EGFR are being used to treat advanced NSCLC and are particularly effective in the presence of EGFR mutations. Monoclonal antibodies have also been developed that block the EGFR at the cell surface and work in conjunction with chemotherapy. Necitumumab is a second-generation fully human IgG1 monoclonal antibody that has shown promise in metastatic NSCLC. The benefit has mostly been restricted to squamous cell lung cancer in the frontline setting. Considering that the survival advantage for these patients was modest, there is a need to discover biomarkers that will predict which patients will likely have the best outcomes. This review focuses on the development and clinical trial experience with necitumumab in NSCLC. Keywords: lung cancer, squamous cell, necitumumab, EGFR |
format |
article |
author |
Thakur MK Wozniak AJ |
author_facet |
Thakur MK Wozniak AJ |
author_sort |
Thakur MK |
title |
Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
title_short |
Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
title_full |
Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
title_fullStr |
Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
title_full_unstemmed |
Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
title_sort |
spotlight on necitumumab in the treatment of non-small-cell lung carcinoma |
publisher |
Dove Medical Press |
publishDate |
2017 |
url |
https://doaj.org/article/1e1088eece5141f0836f45d248062020 |
work_keys_str_mv |
AT thakurmk spotlightonnecitumumabinthetreatmentofnonsmallcelllungcarcinoma AT wozniakaj spotlightonnecitumumabinthetreatmentofnonsmallcelllungcarcinoma |
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1718399505217355776 |