Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial

Stephen P Myers,1 Ann M Mulder,1 Don G Baker,1 Shelley R Robinson,1 Margaret I Rolfe,2 Lyndon Brooks,1 J Helen Fitton,3 1NatMed-Research Unit, Southern Cross University, 2University Centre for Rural Health, Sydney School of Public Health, The University of Sydney, Lismore, NSW, 3Marinova Pt...

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Autores principales:	Myers SP, Mulder AM, Baker DG, Robinson SR, Rolfe MI, Brooks L, Fitton JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	joint pain clinical trial seaweed polysaccharide Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e11c379d8194145a33d6585daffc6a7
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spelling	oai:doaj.org-article:1e11c379d8194145a33d6585daffc6a72021-12-02T01:12:09ZEffects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial1177-5491https://doaj.org/article/1e11c379d8194145a33d6585daffc6a72016-05-01T00:00:00Zhttps://www.dovepress.com/effects-of-fucoidan-from-fucus-vesiculosus-in-reducing-symptoms-of-ost-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Stephen P Myers,1 Ann M Mulder,1 Don G Baker,1 Shelley R Robinson,1 Margaret I Rolfe,2 Lyndon Brooks,1 J Helen Fitton,3 1NatMed-Research Unit, Southern Cross University, 2University Centre for Rural Health, Sydney School of Public Health, The University of Sydney, Lismore, NSW, 3Marinova Pty Ltd, Cambridge, TAS, Australia Purpose: Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms of osteoarthritis (OA) of the hip and knee. Patients and methods: A double-blind randomized controlled trial was carried out to determine the safety and efficacy of a 300 mg dose of a Fucus vesiculosus extract (85% fucoidan) over a 12-week period in a population (n=122) with mild-to-moderate OA of the hip and knee as measured by the validated instrument "Comprehensive Osteoarthritis Test." Safety was measured by assessing cholesterol, liver function, renal function, and hematopoietic function, and closely monitoring adverse events. Result: Ninety-six participants completed the study. The reduction in symptoms of OA was not significantly different from the placebo response. There were no changes in the blood measurements that were of any clinical significance during the course of the study. Conclusion: The F. vesiculosus fucoidan extract was safe and well tolerated. At a dose of 300 mg, the extract showed no difference in reduction of OA symptoms from the placebo. Keywords: joint pain, clinical trial, seaweed, polysaccharide Myers SPMulder AMBaker DGRobinson SRRolfe MIBrooks LFitton JHDove Medical Pressarticlejoint painclinical trialseaweedpolysaccharideMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2016, Iss Issue 1, Pp 81-88 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	joint pain clinical trial seaweed polysaccharide Medicine (General) R5-920
spellingShingle	joint pain clinical trial seaweed polysaccharide Medicine (General) R5-920 Myers SP Mulder AM Baker DG Robinson SR Rolfe MI Brooks L Fitton JH Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
description	Stephen P Myers,1 Ann M Mulder,1 Don G Baker,1 Shelley R Robinson,1 Margaret I Rolfe,2 Lyndon Brooks,1 J Helen Fitton,3 1NatMed-Research Unit, Southern Cross University, 2University Centre for Rural Health, Sydney School of Public Health, The University of Sydney, Lismore, NSW, 3Marinova Pty Ltd, Cambridge, TAS, Australia Purpose: Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms of osteoarthritis (OA) of the hip and knee. Patients and methods: A double-blind randomized controlled trial was carried out to determine the safety and efficacy of a 300 mg dose of a Fucus vesiculosus extract (85% fucoidan) over a 12-week period in a population (n=122) with mild-to-moderate OA of the hip and knee as measured by the validated instrument "Comprehensive Osteoarthritis Test." Safety was measured by assessing cholesterol, liver function, renal function, and hematopoietic function, and closely monitoring adverse events. Result: Ninety-six participants completed the study. The reduction in symptoms of OA was not significantly different from the placebo response. There were no changes in the blood measurements that were of any clinical significance during the course of the study. Conclusion: The F. vesiculosus fucoidan extract was safe and well tolerated. At a dose of 300 mg, the extract showed no difference in reduction of OA symptoms from the placebo. Keywords: joint pain, clinical trial, seaweed, polysaccharide
format	article
author	Myers SP Mulder AM Baker DG Robinson SR Rolfe MI Brooks L Fitton JH
author_facet	Myers SP Mulder AM Baker DG Robinson SR Rolfe MI Brooks L Fitton JH
author_sort	Myers SP
title	Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
title_short	Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
title_full	Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
title_fullStr	Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
title_full_unstemmed	Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
title_sort	effects of fucoidan from fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1e11c379d8194145a33d6585daffc6a7
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Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial

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