Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.
Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, ade...
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2008
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oai:doaj.org-article:1e13e916d8c84a198cf5492130e8020a2021-11-25T06:11:31ZNod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.1932-620310.1371/journal.pone.0002769https://doaj.org/article/1e13e916d8c84a198cf5492130e8020a2008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18648508/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn's disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice.Ulrich MeinzerSophie Esmiol-WelterlinFrederick BarreauDominique BerrebiMonique DussaillantStephane BonacorsiFabrice ChareyreMichiko Niwa-KawakitaCorinne AlbertiGhislaine SterkersClaude VillardThecla LesuffleurMichel PeuchmaurMichael KarinLars EckmannMarco GiovanniniVincent OllendorffHans Wolf-WatzJean-Pierre HugotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 7, p e2769 (2008) |
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Medicine R Science Q Ulrich Meinzer Sophie Esmiol-Welterlin Frederick Barreau Dominique Berrebi Monique Dussaillant Stephane Bonacorsi Fabrice Chareyre Michiko Niwa-Kawakita Corinne Alberti Ghislaine Sterkers Claude Villard Thecla Lesuffleur Michel Peuchmaur Michael Karin Lars Eckmann Marco Giovannini Vincent Ollendorff Hans Wolf-Watz Jean-Pierre Hugot Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. |
| description |
Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn's disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice. |
| format |
article |
| author |
Ulrich Meinzer Sophie Esmiol-Welterlin Frederick Barreau Dominique Berrebi Monique Dussaillant Stephane Bonacorsi Fabrice Chareyre Michiko Niwa-Kawakita Corinne Alberti Ghislaine Sterkers Claude Villard Thecla Lesuffleur Michel Peuchmaur Michael Karin Lars Eckmann Marco Giovannini Vincent Ollendorff Hans Wolf-Watz Jean-Pierre Hugot |
| author_facet |
Ulrich Meinzer Sophie Esmiol-Welterlin Frederick Barreau Dominique Berrebi Monique Dussaillant Stephane Bonacorsi Fabrice Chareyre Michiko Niwa-Kawakita Corinne Alberti Ghislaine Sterkers Claude Villard Thecla Lesuffleur Michel Peuchmaur Michael Karin Lars Eckmann Marco Giovannini Vincent Ollendorff Hans Wolf-Watz Jean-Pierre Hugot |
| author_sort |
Ulrich Meinzer |
| title |
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. |
| title_short |
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. |
| title_full |
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. |
| title_fullStr |
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. |
| title_full_unstemmed |
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. |
| title_sort |
nod2 mediates susceptibility to yersinia pseudotuberculosis in mice. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/1e13e916d8c84a198cf5492130e8020a |
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