Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients

Abstract There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supp...

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Autores principales:	Nasser M. Al-Daghri, Abdul Khader Mohammed, Omar S. Al-Attas, Mohammed Ghouse Ahmed Ansari, Kaiser Wani, Syed D. Hussain, Shaun Sabico, Gyanendra Tripathi, Majed S. Alokail
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e1419b590e743ef9b4a9852332ebf40
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spelling	oai:doaj.org-article:1e1419b590e743ef9b4a9852332ebf402021-12-02T12:32:12ZVitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients10.1038/s41598-017-08621-72045-2322https://doaj.org/article/1e1419b590e743ef9b4a9852332ebf402017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08621-7https://doaj.org/toc/2045-2322Abstract There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months. VDR polymorphisms (Taq-I, Bsm-I, Apa-I and Fok-I) were identified using TaqMan genotyping assays. Vitamin D supplementation significantly increased HOMA β-cell function (p = 0.003) as well as significantly decreased triglycerides, total and LDL-cholesterol (p < 0.001). The lowest increment in 25(OH)D levels was detected in patients with Fok-I CC genotypes (p < 0.0001). With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p < 0.005, 0.01, < 0.001, < 0.005, 0.03 and 0.01, respectively). Similarly, Bsm-I TT genotype carriers showed significant improvements in triglycerides (p = 0.01), insulin and HOMA-IR (p-values < 0.05). In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.Nasser M. Al-DaghriAbdul Khader MohammedOmar S. Al-AttasMohammed Ghouse Ahmed AnsariKaiser WaniSyed D. HussainShaun SabicoGyanendra TripathiMajed S. AlokailNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nasser M. Al-Daghri Abdul Khader Mohammed Omar S. Al-Attas Mohammed Ghouse Ahmed Ansari Kaiser Wani Syed D. Hussain Shaun Sabico Gyanendra Tripathi Majed S. Alokail Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients
description	Abstract There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months. VDR polymorphisms (Taq-I, Bsm-I, Apa-I and Fok-I) were identified using TaqMan genotyping assays. Vitamin D supplementation significantly increased HOMA β-cell function (p = 0.003) as well as significantly decreased triglycerides, total and LDL-cholesterol (p < 0.001). The lowest increment in 25(OH)D levels was detected in patients with Fok-I CC genotypes (p < 0.0001). With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p < 0.005, 0.01, < 0.001, < 0.005, 0.03 and 0.01, respectively). Similarly, Bsm-I TT genotype carriers showed significant improvements in triglycerides (p = 0.01), insulin and HOMA-IR (p-values < 0.05). In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.
format	article
author	Nasser M. Al-Daghri Abdul Khader Mohammed Omar S. Al-Attas Mohammed Ghouse Ahmed Ansari Kaiser Wani Syed D. Hussain Shaun Sabico Gyanendra Tripathi Majed S. Alokail
author_facet	Nasser M. Al-Daghri Abdul Khader Mohammed Omar S. Al-Attas Mohammed Ghouse Ahmed Ansari Kaiser Wani Syed D. Hussain Shaun Sabico Gyanendra Tripathi Majed S. Alokail
author_sort	Nasser M. Al-Daghri
title	Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients
title_short	Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients
title_full	Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients
title_fullStr	Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients
title_full_unstemmed	Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients
title_sort	vitamin d receptor gene polymorphisms modify cardiometabolic response to vitamin d supplementation in t2dm patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1e1419b590e743ef9b4a9852332ebf40
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Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients

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