Meropenem pharmacokinetics in children: series of cases
Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a ser...
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Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
2019
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oai:doaj.org-article:1e164de51cd34e4db007ebe4fdb9c7b22021-11-28T02:46:44ZMeropenem pharmacokinetics in children: series of cases10.30968/rbfhss.2018.093.0022179-59242316-7750https://doaj.org/article/1e164de51cd34e4db007ebe4fdb9c7b22019-10-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/380https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a series of cases, which included 4 children, aged 02-12 years old using meropenem dose empirical, 8/8h in 75% of children. The study was conducted in a pediatric hospital from March 2016 to March 2017. Only one child had the result of the culture of biological material recorded in medical records at the time of collection. We observed high inter-patient variability of pharmacokinetic parameters, however plasma concentrations of meropenem were effective in 100% of the study population considering the parameter 40%f T>CIM to CIM of 0.25μg/mL. Geisa Cristina da Silva AlvesFarah Maria Drumond ChequerCristina SanchesSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 9, Iss 3 (2019) |
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DOAJ |
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EN PT |
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Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 |
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Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Geisa Cristina da Silva Alves Farah Maria Drumond Chequer Cristina Sanches Meropenem pharmacokinetics in children: series of cases |
| description |
Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a series of cases, which included 4 children, aged 02-12 years old using meropenem dose empirical, 8/8h in 75% of children. The study was conducted in a pediatric hospital from March 2016 to March 2017. Only one child had the result of the culture of biological material recorded in medical records at the time of collection. We observed high inter-patient variability of pharmacokinetic parameters, however plasma concentrations of meropenem were effective in 100% of the study population considering the parameter 40%f T>CIM to CIM of 0.25μg/mL.
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| format |
article |
| author |
Geisa Cristina da Silva Alves Farah Maria Drumond Chequer Cristina Sanches |
| author_facet |
Geisa Cristina da Silva Alves Farah Maria Drumond Chequer Cristina Sanches |
| author_sort |
Geisa Cristina da Silva Alves |
| title |
Meropenem pharmacokinetics in children: series of cases |
| title_short |
Meropenem pharmacokinetics in children: series of cases |
| title_full |
Meropenem pharmacokinetics in children: series of cases |
| title_fullStr |
Meropenem pharmacokinetics in children: series of cases |
| title_full_unstemmed |
Meropenem pharmacokinetics in children: series of cases |
| title_sort |
meropenem pharmacokinetics in children: series of cases |
| publisher |
Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| publishDate |
2019 |
| url |
https://doaj.org/article/1e164de51cd34e4db007ebe4fdb9c7b2 |
| work_keys_str_mv |
AT geisacristinadasilvaalves meropenempharmacokineticsinchildrenseriesofcases AT farahmariadrumondchequer meropenempharmacokineticsinchildrenseriesofcases AT cristinasanches meropenempharmacokineticsinchildrenseriesofcases |
| _version_ |
1718408424587264000 |