Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

The proteases of flaviviruses are promising targets for development of specific antiviral drugs. Here, the authors report a high resolution crystal structure of the NS2B-NS3 protease of Zika virus that provides insight into substrate and inhibitor binding.

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Autores principales:	Wint Wint Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Ying Ru Loh, Yaw Bia Tan, Elizabeth Yihui Ng, Julien Lescar, CongBao Kang, Dahai Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e18f150920b449090fe1774d82be133
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spelling	oai:doaj.org-article:1e18f150920b449090fe1774d82be1332021-12-02T15:34:59ZStructure of the NS2B-NS3 protease from Zika virus after self-cleavage10.1038/ncomms134102041-1723https://doaj.org/article/1e18f150920b449090fe1774d82be1332016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13410https://doaj.org/toc/2041-1723The proteases of flaviviruses are promising targets for development of specific antiviral drugs. Here, the authors report a high resolution crystal structure of the NS2B-NS3 protease of Zika virus that provides insight into substrate and inhibitor binding.Wint Wint PhooYan LiZhenzhen ZhangMichelle Yueqi LeeYing Ru LohYaw Bia TanElizabeth Yihui NgJulien LescarCongBao KangDahai LuoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wint Wint Phoo Yan Li Zhenzhen Zhang Michelle Yueqi Lee Ying Ru Loh Yaw Bia Tan Elizabeth Yihui Ng Julien Lescar CongBao Kang Dahai Luo Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
description	The proteases of flaviviruses are promising targets for development of specific antiviral drugs. Here, the authors report a high resolution crystal structure of the NS2B-NS3 protease of Zika virus that provides insight into substrate and inhibitor binding.
format	article
author	Wint Wint Phoo Yan Li Zhenzhen Zhang Michelle Yueqi Lee Ying Ru Loh Yaw Bia Tan Elizabeth Yihui Ng Julien Lescar CongBao Kang Dahai Luo
author_facet	Wint Wint Phoo Yan Li Zhenzhen Zhang Michelle Yueqi Lee Ying Ru Loh Yaw Bia Tan Elizabeth Yihui Ng Julien Lescar CongBao Kang Dahai Luo
author_sort	Wint Wint Phoo
title	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_short	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_full	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_fullStr	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_full_unstemmed	Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
title_sort	structure of the ns2b-ns3 protease from zika virus after self-cleavage
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1e18f150920b449090fe1774d82be133
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Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

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