Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret

Ye Tu,1,2,* Xinxia Wang,3,* Ying Lu,2,* He Zhang,2 Yuan Yu,2 Yan Chen,2 Junjie Liu,2 Zhiguo Sun,2 Lili Cui,4 Jing Gao,2 Yanqiang Zhong2 1Department of Medical Affairs, East Hospital, Tongji University School of Medicine, 2Department of Pharmaceutical Science, School of Pharmacy, Second Military Med...

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Autores principales:	Tu Y, Wang X, Lu Y, Zhang H, Yu Y, Chen Y, Liu J, Sun Z, Cui L, Gao J, Zhong Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	N-trimethyl chitosan nanoparticles Electret Transdermal delivery Protein drugs. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e192cc57c944274bb7dff72baeee96c
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spelling	oai:doaj.org-article:1e192cc57c944274bb7dff72baeee96c2021-12-02T07:43:10ZPromotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret1178-2013https://doaj.org/article/1e192cc57c944274bb7dff72baeee96c2016-10-01T00:00:00Zhttps://www.dovepress.com/promotion-of-the-transdermal-delivery-of-protein-drugs-by-n-trimethyl--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ye Tu,1,2,* Xinxia Wang,3,* Ying Lu,2,* He Zhang,2 Yuan Yu,2 Yan Chen,2 Junjie Liu,2 Zhiguo Sun,2 Lili Cui,4 Jing Gao,2 Yanqiang Zhong2 1Department of Medical Affairs, East Hospital, Tongji University School of Medicine, 2Department of Pharmaceutical Science, School of Pharmacy, Second Military Medical University, 3Department of Pharmacy, East Hospital of Hepatobiliary Surgery, 4Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series of experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, to evaluate the transdermal delivery of protein drugs by TMC NPs in the presence of electret. The results showed that in the presence of electret, the transdermal delivery of protein drugs in TMC NPs was significantly enhanced, as demonstrated by in vitro permeation studies and confocal laser scanning microscopy. Notably, superoxide dismutase-loaded TMC NPs combined with electret exhibited the best inhibitory effect on the edema of the mouse ear. TMC NPs combined with electret represent a novel platform for the transdermal delivery of protein drugs. Keywords: N-trimethyl chitosan nanoparticles, electret, transdermal delivery, protein drugs Tu YWang XLu YZhang HYu YChen YLiu JSun ZCui LGao JZhong YDove Medical PressarticleN-trimethyl chitosan nanoparticlesElectretTransdermal deliveryProtein drugs.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5549-5561 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	N-trimethyl chitosan nanoparticles Electret Transdermal delivery Protein drugs. Medicine (General) R5-920
spellingShingle	N-trimethyl chitosan nanoparticles Electret Transdermal delivery Protein drugs. Medicine (General) R5-920 Tu Y Wang X Lu Y Zhang H Yu Y Chen Y Liu J Sun Z Cui L Gao J Zhong Y Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
description	Ye Tu,1,2,* Xinxia Wang,3,* Ying Lu,2,* He Zhang,2 Yuan Yu,2 Yan Chen,2 Junjie Liu,2 Zhiguo Sun,2 Lili Cui,4 Jing Gao,2 Yanqiang Zhong2 1Department of Medical Affairs, East Hospital, Tongji University School of Medicine, 2Department of Pharmaceutical Science, School of Pharmacy, Second Military Medical University, 3Department of Pharmacy, East Hospital of Hepatobiliary Surgery, 4Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series of experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, to evaluate the transdermal delivery of protein drugs by TMC NPs in the presence of electret. The results showed that in the presence of electret, the transdermal delivery of protein drugs in TMC NPs was significantly enhanced, as demonstrated by in vitro permeation studies and confocal laser scanning microscopy. Notably, superoxide dismutase-loaded TMC NPs combined with electret exhibited the best inhibitory effect on the edema of the mouse ear. TMC NPs combined with electret represent a novel platform for the transdermal delivery of protein drugs. Keywords: N-trimethyl chitosan nanoparticles, electret, transdermal delivery, protein drugs
format	article
author	Tu Y Wang X Lu Y Zhang H Yu Y Chen Y Liu J Sun Z Cui L Gao J Zhong Y
author_facet	Tu Y Wang X Lu Y Zhang H Yu Y Chen Y Liu J Sun Z Cui L Gao J Zhong Y
author_sort	Tu Y
title	Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
title_short	Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
title_full	Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
title_fullStr	Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
title_full_unstemmed	Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
title_sort	promotion of the transdermal delivery of protein drugs by n-trimethyl chitosan nanoparticles combined with polypropylene electret
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1e192cc57c944274bb7dff72baeee96c
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Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret

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