Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

Relatively well conserved domains of influenza A virus (IAV) proteins are potential candidates for the development of a universal IAV vaccine. Here, Deng et al. combine two such conserved antigens (M2e and HA stalk) in a double-layered protein nanoparticle and show that it protects against divergent...

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Autores principales:	Lei Deng, Teena Mohan, Timothy Z. Chang, Gilbert X. Gonzalez, Ye Wang, Young-Man Kwon, Sang-Moo Kang, Richard W. Compans, Julie A. Champion, Bao-Zhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e1b7e376b26409f8f98647986ff3a30
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spelling	oai:doaj.org-article:1e1b7e376b26409f8f98647986ff3a302021-12-02T17:32:32ZDouble-layered protein nanoparticles induce broad protection against divergent influenza A viruses10.1038/s41467-017-02725-42041-1723https://doaj.org/article/1e1b7e376b26409f8f98647986ff3a302018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02725-4https://doaj.org/toc/2041-1723Relatively well conserved domains of influenza A virus (IAV) proteins are potential candidates for the development of a universal IAV vaccine. Here, Deng et al. combine two such conserved antigens (M2e and HA stalk) in a double-layered protein nanoparticle and show that it protects against divergent IAVs in mice.Lei DengTeena MohanTimothy Z. ChangGilbert X. GonzalezYe WangYoung-Man KwonSang-Moo KangRichard W. CompansJulie A. ChampionBao-Zhong WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Deng Teena Mohan Timothy Z. Chang Gilbert X. Gonzalez Ye Wang Young-Man Kwon Sang-Moo Kang Richard W. Compans Julie A. Champion Bao-Zhong Wang Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
description	Relatively well conserved domains of influenza A virus (IAV) proteins are potential candidates for the development of a universal IAV vaccine. Here, Deng et al. combine two such conserved antigens (M2e and HA stalk) in a double-layered protein nanoparticle and show that it protects against divergent IAVs in mice.
format	article
author	Lei Deng Teena Mohan Timothy Z. Chang Gilbert X. Gonzalez Ye Wang Young-Man Kwon Sang-Moo Kang Richard W. Compans Julie A. Champion Bao-Zhong Wang
author_facet	Lei Deng Teena Mohan Timothy Z. Chang Gilbert X. Gonzalez Ye Wang Young-Man Kwon Sang-Moo Kang Richard W. Compans Julie A. Champion Bao-Zhong Wang
author_sort	Lei Deng
title	Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
title_short	Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
title_full	Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
title_fullStr	Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
title_full_unstemmed	Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
title_sort	double-layered protein nanoparticles induce broad protection against divergent influenza a viruses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1e1b7e376b26409f8f98647986ff3a30
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Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

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