Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.

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Autores principales:	Sihan Li, Andrew Mecca, Jeewoo Kim, Giusy A. Caprara, Elizabeth L. Wagner, Ting-Ting Du, Leonid Petrov, Wenhao Xu, Runjia Cui, Ivan T. Rebustini, Bechara Kachar, Anthony W. Peng, Jung-Bum Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e1c4ebb707d4e36929a5c7886e6304d
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spelling	oai:doaj.org-article:1e1c4ebb707d4e36929a5c7886e6304d2021-12-02T16:50:04ZMyosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex10.1038/s41467-020-15936-z2041-1723https://doaj.org/article/1e1c4ebb707d4e36929a5c7886e6304d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15936-zhttps://doaj.org/toc/2041-1723How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.Sihan LiAndrew MeccaJeewoo KimGiusy A. CapraraElizabeth L. WagnerTing-Ting DuLeonid PetrovWenhao XuRunjia CuiIvan T. RebustiniBechara KacharAnthony W. PengJung-Bum ShinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sihan Li Andrew Mecca Jeewoo Kim Giusy A. Caprara Elizabeth L. Wagner Ting-Ting Du Leonid Petrov Wenhao Xu Runjia Cui Ivan T. Rebustini Bechara Kachar Anthony W. Peng Jung-Bum Shin Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
description	How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.
format	article
author	Sihan Li Andrew Mecca Jeewoo Kim Giusy A. Caprara Elizabeth L. Wagner Ting-Ting Du Leonid Petrov Wenhao Xu Runjia Cui Ivan T. Rebustini Bechara Kachar Anthony W. Peng Jung-Bum Shin
author_facet	Sihan Li Andrew Mecca Jeewoo Kim Giusy A. Caprara Elizabeth L. Wagner Ting-Ting Du Leonid Petrov Wenhao Xu Runjia Cui Ivan T. Rebustini Bechara Kachar Anthony W. Peng Jung-Bum Shin
author_sort	Sihan Li
title	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_short	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_full	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_fullStr	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_full_unstemmed	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_sort	myosin-viia is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1e1c4ebb707d4e36929a5c7886e6304d
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Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

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