Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice

Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes f...

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Autores principales:	Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa
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spelling	oai:doaj.org-article:1e1c9269b742425ab2397a10869c4faa2021-12-02T16:28:52ZScavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice10.1038/s41467-020-17915-w2041-1723https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17915-whttps://doaj.org/toc/2041-1723Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.Huan TaoJiansheng HuangPatricia G. YanceyValery YermalitskyJohn L. BlakemoreYoumin ZhangLei DingIrene Zagol-IkapitteFei YeVenkataraman AmarnathOlivier BoutaudJohn A. OatesL. Jackson RobertsSean S. DaviesMacRae F. LintonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
description	Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.
format	article
author	Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton
author_facet	Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton
author_sort	Huan Tao
title	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_short	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_full	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_fullStr	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_full_unstemmed	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_sort	scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic ldlr −/− mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa
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Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice

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