Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.

<h4>Background</h4>Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-ce...

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Autores principales:	Nicola Napoli, Rocky Strollo, Dario Pitocco, Carla Bizzarri, Ernesto Maddaloni, Daria Maggi, Silvia Manfrini, Ann Schwartz, Paolo Pozzilli, IMDIAB Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e1eb7bbd7b6481b9dbfcb3d2031e405
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spelling	oai:doaj.org-article:1e1eb7bbd7b6481b9dbfcb3d2031e4052021-11-18T07:56:54ZEffect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.1932-620310.1371/journal.pone.0056488https://doaj.org/article/1e1eb7bbd7b6481b9dbfcb3d2031e4052013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437144/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined.<h4>Methodology/principal findings</h4>We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 µg calcitriol per day or placebo (1:1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (P<0.01) while no other metabolic parameters as HbA1c and C-peptide differed between gender. No significant correlations were found in relation to HbA1c, insulin requirement and C-peptide. At 1 year follow-up, no significant differences were observed between calcitriol and placebo groups for osteocalcin and β-CrossLaps. In the placebo group osteocalcin levels were unrelated with parameters of metabolic control, such as C-peptide, insulin requirement or HbA1c. Changes of C-peptide, insulin requirement and HbA1c were not related to osteocalcin levels.<h4>Conclusions</h4>Supplementation with 0.25 µg calcitriol per day to patients with new-onset T1D does not affect circulating markers of bone turnover. OC levels were unrelated to β-cell function and other metabolic parameters suggesting that OC is ineffective to control pancreatic function in presence of aggressive autoimmune destruction.Nicola NapoliRocky StrolloDario PitoccoCarla BizzarriErnesto MaddaloniDaria MaggiSilvia ManfriniAnn SchwartzPaolo PozzilliIMDIAB GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56488 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicola Napoli Rocky Strollo Dario Pitocco Carla Bizzarri Ernesto Maddaloni Daria Maggi Silvia Manfrini Ann Schwartz Paolo Pozzilli IMDIAB Group Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
description	<h4>Background</h4>Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined.<h4>Methodology/principal findings</h4>We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 µg calcitriol per day or placebo (1:1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (P<0.01) while no other metabolic parameters as HbA1c and C-peptide differed between gender. No significant correlations were found in relation to HbA1c, insulin requirement and C-peptide. At 1 year follow-up, no significant differences were observed between calcitriol and placebo groups for osteocalcin and β-CrossLaps. In the placebo group osteocalcin levels were unrelated with parameters of metabolic control, such as C-peptide, insulin requirement or HbA1c. Changes of C-peptide, insulin requirement and HbA1c were not related to osteocalcin levels.<h4>Conclusions</h4>Supplementation with 0.25 µg calcitriol per day to patients with new-onset T1D does not affect circulating markers of bone turnover. OC levels were unrelated to β-cell function and other metabolic parameters suggesting that OC is ineffective to control pancreatic function in presence of aggressive autoimmune destruction.
format	article
author	Nicola Napoli Rocky Strollo Dario Pitocco Carla Bizzarri Ernesto Maddaloni Daria Maggi Silvia Manfrini Ann Schwartz Paolo Pozzilli IMDIAB Group
author_facet	Nicola Napoli Rocky Strollo Dario Pitocco Carla Bizzarri Ernesto Maddaloni Daria Maggi Silvia Manfrini Ann Schwartz Paolo Pozzilli IMDIAB Group
author_sort	Nicola Napoli
title	Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
title_short	Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
title_full	Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
title_fullStr	Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
title_full_unstemmed	Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
title_sort	effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1e1eb7bbd7b6481b9dbfcb3d2031e405
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Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.

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