Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition

NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this signaling checkpoint is defective in X-linked lymphop...

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Autores principales:	Hyung-Joon Kwon, Go-Eun Choi, Sangryeol Ryu, Soon Jae Kwon, Sun Chang Kim, Claire Booth, Kim E. Nichols, Hun Sik Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e231bdd2f5b49878bcef0ac1df70c15
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spelling	oai:doaj.org-article:1e231bdd2f5b49878bcef0ac1df70c152021-12-02T15:35:21ZStepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition10.1038/ncomms116862041-1723https://doaj.org/article/1e231bdd2f5b49878bcef0ac1df70c152016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11686https://doaj.org/toc/2041-1723NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this signaling checkpoint is defective in X-linked lymphoproliferative disease.Hyung-Joon KwonGo-Eun ChoiSangryeol RyuSoon Jae KwonSun Chang KimClaire BoothKim E. NicholsHun Sik KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyung-Joon Kwon Go-Eun Choi Sangryeol Ryu Soon Jae Kwon Sun Chang Kim Claire Booth Kim E. Nichols Hun Sik Kim Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
description	NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this signaling checkpoint is defective in X-linked lymphoproliferative disease.
format	article
author	Hyung-Joon Kwon Go-Eun Choi Sangryeol Ryu Soon Jae Kwon Sun Chang Kim Claire Booth Kim E. Nichols Hun Sik Kim
author_facet	Hyung-Joon Kwon Go-Eun Choi Sangryeol Ryu Soon Jae Kwon Sun Chang Kim Claire Booth Kim E. Nichols Hun Sik Kim
author_sort	Hyung-Joon Kwon
title	Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
title_short	Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
title_full	Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
title_fullStr	Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
title_full_unstemmed	Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
title_sort	stepwise phosphorylation of p65 promotes nf-κb activation and nk cell responses during target cell recognition
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1e231bdd2f5b49878bcef0ac1df70c15
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_version_	1718386582128427008

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition

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