D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep

The physiological function of endogenous D-serine remains a mystery. Here the authors show that endogenous D-serine plays an important role in regulating sleep and that, while the D-serine synthesizing enzyme serine racemase (SR) is expressed both in the nervous system and the intestines, the SR in...

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Autores principales:	Xihuimin Dai, Enxing Zhou, Wei Yang, Xiaohui Zhang, Wenxia Zhang, Yi Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e235a5f588c47bab7b345eb60841fc2
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spelling	oai:doaj.org-article:1e235a5f588c47bab7b345eb60841fc22021-12-02T15:36:02ZD-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep10.1038/s41467-019-09544-92041-1723https://doaj.org/article/1e235a5f588c47bab7b345eb60841fc22019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09544-9https://doaj.org/toc/2041-1723The physiological function of endogenous D-serine remains a mystery. Here the authors show that endogenous D-serine plays an important role in regulating sleep and that, while the D-serine synthesizing enzyme serine racemase (SR) is expressed both in the nervous system and the intestines, the SR in the intestine is shown to be functionally sufficient for sleep regulation.Xihuimin DaiEnxing ZhouWei YangXiaohui ZhangWenxia ZhangYi RaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xihuimin Dai Enxing Zhou Wei Yang Xiaohui Zhang Wenxia Zhang Yi Rao D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
description	The physiological function of endogenous D-serine remains a mystery. Here the authors show that endogenous D-serine plays an important role in regulating sleep and that, while the D-serine synthesizing enzyme serine racemase (SR) is expressed both in the nervous system and the intestines, the SR in the intestine is shown to be functionally sufficient for sleep regulation.
format	article
author	Xihuimin Dai Enxing Zhou Wei Yang Xiaohui Zhang Wenxia Zhang Yi Rao
author_facet	Xihuimin Dai Enxing Zhou Wei Yang Xiaohui Zhang Wenxia Zhang Yi Rao
author_sort	Xihuimin Dai
title	D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
title_short	D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
title_full	D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
title_fullStr	D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
title_full_unstemmed	D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
title_sort	d-serine made by serine racemase in drosophila intestine plays a physiological role in sleep
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1e235a5f588c47bab7b345eb60841fc2
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D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep

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