Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Piotr Pardak, Rafał Filip, Jarosław Woliński, Maciej Krzaczek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastroesophageal reflux sleep apnea ghrelin obestatin leptin Medicine R
Acceso en línea:	https://doaj.org/article/1e257bd5cae3436eabdbd19a559483b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e257bd5cae3436eabdbd19a559483b3
record_format	dspace
spelling	oai:doaj.org-article:1e257bd5cae3436eabdbd19a559483b32021-11-11T17:48:00ZAssociations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux10.3390/jcm102151952077-0383https://doaj.org/article/1e257bd5cae3436eabdbd19a559483b32021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5195https://doaj.org/toc/2077-0383Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD in patients with OSA. The study included 58 patients hospitalized due to clinical suspicion of sleep disorders during sleep. All patients underwent a sleep study, and blood samples were collected overnight for hormonal tests. Survey data concerning symptoms of GERD, gastroscopy, and esophageal pH monitoring results were included in the study. In patients with OSA, GERD was twice as common when compared to the group without OSA. Among subjects with severe sleep apnea (AHI > 30; <i>n</i> = 31; 53%), we observed lower ghrelin levels, especially in the second half of the night and in the morning (<i>p</i><sub>5.00</sub> = 0.0207; <i>p</i><sub>7.00</sub> = 0.0344); the presence of OSA had no effect on obestatin and leptin levels. No significant differences in hormonal levels were observed between the groups depending on the diagnosis of GERD. However, correlations of ghrelin levels with the severity of esophagitis, leptin and ghrelin levels with the severity of GERD symptoms, and leptin levels with lower esophageal pH were found. GERD is more frequent among patients with OSA. In both GERD and OSA, deviations were observed in the levels of ghrelin and leptin. However, our analysis demonstrates that the relationship between OSA and GERD does not result from these disorders.Piotr PardakRafał FilipJarosław WolińskiMaciej KrzaczekMDPI AGarticlegastroesophageal refluxsleep apneaghrelinobestatinleptinMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5195, p 5195 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastroesophageal reflux sleep apnea ghrelin obestatin leptin Medicine R
spellingShingle	gastroesophageal reflux sleep apnea ghrelin obestatin leptin Medicine R Piotr Pardak Rafał Filip Jarosław Woliński Maciej Krzaczek Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux
description	Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD in patients with OSA. The study included 58 patients hospitalized due to clinical suspicion of sleep disorders during sleep. All patients underwent a sleep study, and blood samples were collected overnight for hormonal tests. Survey data concerning symptoms of GERD, gastroscopy, and esophageal pH monitoring results were included in the study. In patients with OSA, GERD was twice as common when compared to the group without OSA. Among subjects with severe sleep apnea (AHI > 30; <i>n</i> = 31; 53%), we observed lower ghrelin levels, especially in the second half of the night and in the morning (<i>p</i><sub>5.00</sub> = 0.0207; <i>p</i><sub>7.00</sub> = 0.0344); the presence of OSA had no effect on obestatin and leptin levels. No significant differences in hormonal levels were observed between the groups depending on the diagnosis of GERD. However, correlations of ghrelin levels with the severity of esophagitis, leptin and ghrelin levels with the severity of GERD symptoms, and leptin levels with lower esophageal pH were found. GERD is more frequent among patients with OSA. In both GERD and OSA, deviations were observed in the levels of ghrelin and leptin. However, our analysis demonstrates that the relationship between OSA and GERD does not result from these disorders.
format	article
author	Piotr Pardak Rafał Filip Jarosław Woliński Maciej Krzaczek
author_facet	Piotr Pardak Rafał Filip Jarosław Woliński Maciej Krzaczek
author_sort	Piotr Pardak
title	Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux
title_short	Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux
title_full	Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux
title_fullStr	Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux
title_full_unstemmed	Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux
title_sort	associations of obstructive sleep apnea, obestatin, leptin, and ghrelin with gastroesophageal reflux
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1e257bd5cae3436eabdbd19a559483b3
work_keys_str_mv	AT piotrpardak associationsofobstructivesleepapneaobestatinleptinandghrelinwithgastroesophagealreflux AT rafałfilip associationsofobstructivesleepapneaobestatinleptinandghrelinwithgastroesophagealreflux AT jarosławwolinski associationsofobstructivesleepapneaobestatinleptinandghrelinwithgastroesophagealreflux AT maciejkrzaczek associationsofobstructivesleepapneaobestatinleptinandghrelinwithgastroesophagealreflux
_version_	1718431989788311552

Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

Ejemplares similares