SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.

<h4>Objectives</h4>To study the expression pattern and prognostic significance of SAMSN1 in glioma.<h4>Methods</h4>Affymetrix and Arrystar gene microarray data in the setting of glioma was analyzed to preliminarily study the expression pattern of SAMSN1 in glioma tissues, and...

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Autores principales:	Yong Yan, Lei Zhang, Tao Xu, Jinxu Zhou, Rong Qin, Chao Chen, Yongxiang Zou, Da Fu, Guohan Hu, Juxiang Chen, Yicheng Lu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e282bd3c5764ff3940a020836a6ef8d
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spelling	oai:doaj.org-article:1e282bd3c5764ff3940a020836a6ef8d2021-11-18T08:44:58ZSAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.1932-620310.1371/journal.pone.0081905https://doaj.org/article/1e282bd3c5764ff3940a020836a6ef8d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278465/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To study the expression pattern and prognostic significance of SAMSN1 in glioma.<h4>Methods</h4>Affymetrix and Arrystar gene microarray data in the setting of glioma was analyzed to preliminarily study the expression pattern of SAMSN1 in glioma tissues, and Hieratical clustering of gene microarray data was performed to filter out genes that have prognostic value in malignant glioma. Survival analysis by Kaplan-Meier estimates stratified by SAMSN1 expression was then made based on the data of more than 500 GBM cases provided by The Cancer Genome Atlas (TCGA) project. At last, we detected the expression of SAMSN1 in large numbers of glioma and normal brain tissue samples using Tissue Microarray (TMA). Survival analysis by Kaplan-Meier estimates in each grade of glioma was stratified by SAMSN1 expression. Multivariate survival analysis was made by Cox proportional hazards regression models in corresponding groups of glioma.<h4>Results</h4>With the expression data of SAMSN1 and 68 other genes, high-grade glioma could be classified into two groups with clearly different prognoses. Gene and large sample tissue microarrays showed high expression of SAMSN1 in glioma particularly in GBM. Survival analysis based on the TCGA GBM data matrix and TMA multi-grade glioma dataset found that SAMSN1 expression was closely related to the prognosis of GBM, either PFS or OS (P<0.05). Multivariate survival analysis with Cox proportional hazards regression models confirmed that high expression of SAMSN1 was a strong risk factor for PFS and OS of GBM patients.<h4>Conclusion</h4>SAMSN1 is over-expressed in glioma as compared with that found in normal brains, especially in GBM. High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of GBM.Yong YanLei ZhangTao XuJinxu ZhouRong QinChao ChenYongxiang ZouDa FuGuohan HuJuxiang ChenYicheng LuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81905 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Yan Lei Zhang Tao Xu Jinxu Zhou Rong Qin Chao Chen Yongxiang Zou Da Fu Guohan Hu Juxiang Chen Yicheng Lu SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
description	<h4>Objectives</h4>To study the expression pattern and prognostic significance of SAMSN1 in glioma.<h4>Methods</h4>Affymetrix and Arrystar gene microarray data in the setting of glioma was analyzed to preliminarily study the expression pattern of SAMSN1 in glioma tissues, and Hieratical clustering of gene microarray data was performed to filter out genes that have prognostic value in malignant glioma. Survival analysis by Kaplan-Meier estimates stratified by SAMSN1 expression was then made based on the data of more than 500 GBM cases provided by The Cancer Genome Atlas (TCGA) project. At last, we detected the expression of SAMSN1 in large numbers of glioma and normal brain tissue samples using Tissue Microarray (TMA). Survival analysis by Kaplan-Meier estimates in each grade of glioma was stratified by SAMSN1 expression. Multivariate survival analysis was made by Cox proportional hazards regression models in corresponding groups of glioma.<h4>Results</h4>With the expression data of SAMSN1 and 68 other genes, high-grade glioma could be classified into two groups with clearly different prognoses. Gene and large sample tissue microarrays showed high expression of SAMSN1 in glioma particularly in GBM. Survival analysis based on the TCGA GBM data matrix and TMA multi-grade glioma dataset found that SAMSN1 expression was closely related to the prognosis of GBM, either PFS or OS (P<0.05). Multivariate survival analysis with Cox proportional hazards regression models confirmed that high expression of SAMSN1 was a strong risk factor for PFS and OS of GBM patients.<h4>Conclusion</h4>SAMSN1 is over-expressed in glioma as compared with that found in normal brains, especially in GBM. High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of GBM.
format	article
author	Yong Yan Lei Zhang Tao Xu Jinxu Zhou Rong Qin Chao Chen Yongxiang Zou Da Fu Guohan Hu Juxiang Chen Yicheng Lu
author_facet	Yong Yan Lei Zhang Tao Xu Jinxu Zhou Rong Qin Chao Chen Yongxiang Zou Da Fu Guohan Hu Juxiang Chen Yicheng Lu
author_sort	Yong Yan
title	SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
title_short	SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
title_full	SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
title_fullStr	SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
title_full_unstemmed	SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
title_sort	samsn1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1e282bd3c5764ff3940a020836a6ef8d
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SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.

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