Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study

Lingling Li,1,2,* Qinchang Chen,1,* Qingui Chen,3 Ridong Wu,1 Shenming Wang,1 Chen Yao1 1Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People&am...

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Autores principales:	Li L, Chen Q, Wu R, Wang S, Yao C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	blood glucose critical care mortality retrospective studies Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1e286e2eeeb44df5ab987aa38e47d154
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spelling	oai:doaj.org-article:1e286e2eeeb44df5ab987aa38e47d1542021-12-02T11:48:14ZAssociation Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study1178-7007https://doaj.org/article/1e286e2eeeb44df5ab987aa38e47d1542020-04-01T00:00:00Zhttps://www.dovepress.com/association-between-blood-glucose-within-24-hours-after-intensive-care-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lingling Li,1,2,* Qinchang Chen,1,* Qingui Chen,3 Ridong Wu,1 Shenming Wang,1 Chen Yao1 1Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Medical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shenming Wang; Chen YaoDepartment of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Road 2, Guangzhou, People’s Republic of ChinaEmail shenmingwang@hotmail.com; yaochen@mail.sysu.edu.cnPurpose: The aim of this study was to evaluate the association between blood glucose within 24 hours after intensive care unit (ICU) admission and prognosis.Patients and Methods: A retrospective cohort study was conducted using data from a large critical care database. Patients who had a length of ICU stay ≥ 24 hours and at least two blood glucose records within 24 hours after ICU admission were included and hospital mortality was chosen as the primary outcome. The average, minimum, and maximum blood glucose within 24 hours after ICU admission were a priori selected as exposures and associations between each exposure and outcomes were assessed after adjusted for potential confounders.Results: A total of  14,237 patients were included finally with an average age of 62.9± 17.7 years and a mean SAPS II on admission of 34 (26– 44). Among the study population, 20.2% (2872/14,237) had uncomplicated diabetes, and 6.7% (953/14,237) had complicated diabetes. Lowest hospital mortality rate was observed in the stratum with an average blood glucose ranged 110– 140 mg/dL, a minimum blood glucose ranged 80– 110 mg/dL, and a maximum blood glucose ranged 110– 140 mg/dL. After adjusted for confounders including age, sex, disease severity scores and comorbidities, an average blood glucose ranged  110– 140 mg/dL, a minimum blood glucose ranged 80– 110 mg/dL, and a maximum blood glucose ranged 110– 140 mg/dL were associated with the lowest risk of hospital mortality. Consistent results were found among patients without diabetes in the subgroup analyses stratified by diabetes.Conclusion: A range of 110– 140 mg/dL for average and maximum blood glucose and a range of 80– 110 mg/dL for minimum blood glucose within 24 hours after ICU admission predicted better prognosis especially among patients without diabetes.Keywords: blood glucose, critical care, mortality, retrospective studiesLi LChen QChen QWu RWang SYao CDove Medical Pressarticleblood glucosecritical caremortalityretrospective studiesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1305-1315 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood glucose critical care mortality retrospective studies Specialties of internal medicine RC581-951
spellingShingle	blood glucose critical care mortality retrospective studies Specialties of internal medicine RC581-951 Li L Chen Q Chen Q Wu R Wang S Yao C Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study
description	Lingling Li,1,2,* Qinchang Chen,1,* Qingui Chen,3 Ridong Wu,1 Shenming Wang,1 Chen Yao1 1Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Medical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shenming Wang; Chen YaoDepartment of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Road 2, Guangzhou, People’s Republic of ChinaEmail shenmingwang@hotmail.com; yaochen@mail.sysu.edu.cnPurpose: The aim of this study was to evaluate the association between blood glucose within 24 hours after intensive care unit (ICU) admission and prognosis.Patients and Methods: A retrospective cohort study was conducted using data from a large critical care database. Patients who had a length of ICU stay ≥ 24 hours and at least two blood glucose records within 24 hours after ICU admission were included and hospital mortality was chosen as the primary outcome. The average, minimum, and maximum blood glucose within 24 hours after ICU admission were a priori selected as exposures and associations between each exposure and outcomes were assessed after adjusted for potential confounders.Results: A total of  14,237 patients were included finally with an average age of 62.9± 17.7 years and a mean SAPS II on admission of 34 (26– 44). Among the study population, 20.2% (2872/14,237) had uncomplicated diabetes, and 6.7% (953/14,237) had complicated diabetes. Lowest hospital mortality rate was observed in the stratum with an average blood glucose ranged 110– 140 mg/dL, a minimum blood glucose ranged 80– 110 mg/dL, and a maximum blood glucose ranged 110– 140 mg/dL. After adjusted for confounders including age, sex, disease severity scores and comorbidities, an average blood glucose ranged  110– 140 mg/dL, a minimum blood glucose ranged 80– 110 mg/dL, and a maximum blood glucose ranged 110– 140 mg/dL were associated with the lowest risk of hospital mortality. Consistent results were found among patients without diabetes in the subgroup analyses stratified by diabetes.Conclusion: A range of 110– 140 mg/dL for average and maximum blood glucose and a range of 80– 110 mg/dL for minimum blood glucose within 24 hours after ICU admission predicted better prognosis especially among patients without diabetes.Keywords: blood glucose, critical care, mortality, retrospective studies
format	article
author	Li L Chen Q Chen Q Wu R Wang S Yao C
author_facet	Li L Chen Q Chen Q Wu R Wang S Yao C
author_sort	Li L
title	Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study
title_short	Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study
title_full	Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study
title_fullStr	Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study
title_full_unstemmed	Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study
title_sort	association between blood glucose within 24 hours after intensive care unit admission and prognosis: a retrospective cohort study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1e286e2eeeb44df5ab987aa38e47d154
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Association Between Blood Glucose Within 24 Hours After Intensive Care Unit Admission and Prognosis: A Retrospective Cohort Study

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