Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.

<h4>Objective</h4>To identify the risk factors and source of infection leading to human infections with the Influenza A(H7N9) virus in urban and rural areas.<h4>Methods</h4>We conducted a case-control investigation to identify potential exposures and risk factors. Controls we...

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Autores principales: Fan He, Meng Zhang, Xinyi Wang, Haocheng Wu, Xiaopeng Shang, Fudong Li, Chen Wu, Junfen Lin, Bao-Ping Zhu
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:1e2936b32752455ea9091f1a477f98bb2021-11-18T08:21:06ZDistinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.1932-620310.1371/journal.pone.0095015https://doaj.org/article/1e2936b32752455ea9091f1a477f98bb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24789082/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To identify the risk factors and source of infection leading to human infections with the Influenza A(H7N9) virus in urban and rural areas.<h4>Methods</h4>We conducted a case-control investigation to identify potential exposures and risk factors. Controls were randomly selected from the same community as the cases using random digit dialing. We used exact conditional logistic regression to evaluate the exposures and risk factors, stratified by urban and rural residence.<h4>Results</h4>Buying live or freshly slaughtered poultry from a market was significantly associated with illness onset among both urban [48% of 25 case-patients and 12% of 125 control-persons, adjusted odds ratio (AOR) = 19, 95% CI: 2.3-929] and rural (33% of 18 case-patients and 8.9% of 90 control-persons, AOR = 13, 95% CI:1.5-∞) residents. In rural area, tending to home-raised poultry (56% of 18 case-patients and 10% of 90 control-persons, AOR = 57, 95% CI: 7.5-∞) and existence of a poultry farm in the vicinity of the residence (28% of 18 case-patients and 5.6% of 90 control-persons, AOR = 37, 95% CI: 3.8-∞) were also significantly associated with disease onset. Presence of underlying medical conditions was a significant risk factor for urban residents (76% of 25 case-patients and 13% of 125 control-persons, AOR = 49, 95% CI: 7.1-2132).<h4>Conclusions</h4>Buying live or freshly slaughtered poultry from a market is a risk factor for both urban and rural residents, tending to home-raised poultry and existence of a poultry farm in the vicinity of the residence are risk factors unique for rural residents. The virus might have been in stealth circulation in the poultry population before infecting humans. We recommend strict poultry market management and multisectoral collaboration to identify the extent of poultry infection in China.Fan HeMeng ZhangXinyi WangHaocheng WuXiaopeng ShangFudong LiChen WuJunfen LinBao-Ping ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e95015 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Fan He
Meng Zhang
Xinyi Wang
Haocheng Wu
Xiaopeng Shang
Fudong Li
Chen Wu
Junfen Lin
Bao-Ping Zhu
Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.
description <h4>Objective</h4>To identify the risk factors and source of infection leading to human infections with the Influenza A(H7N9) virus in urban and rural areas.<h4>Methods</h4>We conducted a case-control investigation to identify potential exposures and risk factors. Controls were randomly selected from the same community as the cases using random digit dialing. We used exact conditional logistic regression to evaluate the exposures and risk factors, stratified by urban and rural residence.<h4>Results</h4>Buying live or freshly slaughtered poultry from a market was significantly associated with illness onset among both urban [48% of 25 case-patients and 12% of 125 control-persons, adjusted odds ratio (AOR) = 19, 95% CI: 2.3-929] and rural (33% of 18 case-patients and 8.9% of 90 control-persons, AOR = 13, 95% CI:1.5-∞) residents. In rural area, tending to home-raised poultry (56% of 18 case-patients and 10% of 90 control-persons, AOR = 57, 95% CI: 7.5-∞) and existence of a poultry farm in the vicinity of the residence (28% of 18 case-patients and 5.6% of 90 control-persons, AOR = 37, 95% CI: 3.8-∞) were also significantly associated with disease onset. Presence of underlying medical conditions was a significant risk factor for urban residents (76% of 25 case-patients and 13% of 125 control-persons, AOR = 49, 95% CI: 7.1-2132).<h4>Conclusions</h4>Buying live or freshly slaughtered poultry from a market is a risk factor for both urban and rural residents, tending to home-raised poultry and existence of a poultry farm in the vicinity of the residence are risk factors unique for rural residents. The virus might have been in stealth circulation in the poultry population before infecting humans. We recommend strict poultry market management and multisectoral collaboration to identify the extent of poultry infection in China.
format article
author Fan He
Meng Zhang
Xinyi Wang
Haocheng Wu
Xiaopeng Shang
Fudong Li
Chen Wu
Junfen Lin
Bao-Ping Zhu
author_facet Fan He
Meng Zhang
Xinyi Wang
Haocheng Wu
Xiaopeng Shang
Fudong Li
Chen Wu
Junfen Lin
Bao-Ping Zhu
author_sort Fan He
title Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.
title_short Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.
title_full Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.
title_fullStr Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.
title_full_unstemmed Distinct risk profiles for human infections with the Influenza A(H7N9) virus among rural and urban residents: Zhejiang Province, China, 2013.
title_sort distinct risk profiles for human infections with the influenza a(h7n9) virus among rural and urban residents: zhejiang province, china, 2013.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/1e2936b32752455ea9091f1a477f98bb
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