Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy

Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood. This study aims to evaluate the influence of the fluctuating absolute numbers of lymphocyte subpopulations...

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Autores principales:	Hui Li MD, Hong Yu MM, Shaowei Lan MD, Dandan Zhao MB, Yan Liu MM, Ying Cheng MB
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1e29bee7ae3a4d18a3743d9f71f1fd51
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spelling	oai:doaj.org-article:1e29bee7ae3a4d18a3743d9f71f1fd512021-12-02T08:03:24ZAberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy1533-033810.1177/15330338211039948https://doaj.org/article/1e29bee7ae3a4d18a3743d9f71f1fd512021-12-01T00:00:00Zhttps://doi.org/10.1177/15330338211039948https://doaj.org/toc/1533-0338Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood. This study aims to evaluate the influence of the fluctuating absolute numbers of lymphocyte subpopulations in peripheral blood of patients with small cell lung cancer. Methods: The absolute counts and percentages of lymphocyte subsets in peripheral blood of 329 patients with small cell lung cancer were retrospectively analyzed. The numbers of CD3 + , CD3 + CD4 + , and CD3 + CD8 + T lymphocytes, CD3 − CD19 + B lymphocytes, and CD3 − CD16 + CD56 + NK cells were evaluated by flow cytometry. Their relationship with the patients’ clinical characteristics were statistically evaluated. Results: The CD4/CD8 values derived from the absolute number and percentage of CD3 + CD4 + cells divided by CD3 + CD8 + cells were identical (1.86 ± 0.99). There was no association between any of the lymphocyte subsets levels and age/sex of the 329 patients with small cell lung cancer. The patients with advanced stage had a reduction in CD3 + and CD3 + CD4 + T cell counts and a decreased CD4/CD8 ratio. The levels of CD3 + CD4 + T cells, CD3 − CD19 + B cells, CD3 − CD16 + CD56 + NK cells, and CD4/CD8 ratio were associated with advanced tumor-node-metastasis stage. Patients who had undergone radiotherapy were characterized by lymphopenia with lower numbers of CD3 + , CD3 + CD4 + , CD3 + CD8 + T lymphocyte, B lymphocyte, NK cell, and CD4/CD8 ratio. The evaluation of individual CD4/CD8 ratio should be combined with other clinical parameters. Conclusions: Patients with small cell lung cancer have altered lymphocyte homeostasis. Lymphopenia was a long-lasting feature of the enrolled patients who were treated with radiotherapy. The available lymphocyte subsets levels might be used to manage the clinical treatment scheme.Hui Li MDHong Yu MMShaowei Lan MDDandan Zhao MBYan Liu MMYing Cheng MBSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTechnology in Cancer Research & Treatment, Vol 20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hui Li MD Hong Yu MM Shaowei Lan MD Dandan Zhao MB Yan Liu MM Ying Cheng MB Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
description	Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood. This study aims to evaluate the influence of the fluctuating absolute numbers of lymphocyte subpopulations in peripheral blood of patients with small cell lung cancer. Methods: The absolute counts and percentages of lymphocyte subsets in peripheral blood of 329 patients with small cell lung cancer were retrospectively analyzed. The numbers of CD3 + , CD3 + CD4 + , and CD3 + CD8 + T lymphocytes, CD3 − CD19 + B lymphocytes, and CD3 − CD16 + CD56 + NK cells were evaluated by flow cytometry. Their relationship with the patients’ clinical characteristics were statistically evaluated. Results: The CD4/CD8 values derived from the absolute number and percentage of CD3 + CD4 + cells divided by CD3 + CD8 + cells were identical (1.86 ± 0.99). There was no association between any of the lymphocyte subsets levels and age/sex of the 329 patients with small cell lung cancer. The patients with advanced stage had a reduction in CD3 + and CD3 + CD4 + T cell counts and a decreased CD4/CD8 ratio. The levels of CD3 + CD4 + T cells, CD3 − CD19 + B cells, CD3 − CD16 + CD56 + NK cells, and CD4/CD8 ratio were associated with advanced tumor-node-metastasis stage. Patients who had undergone radiotherapy were characterized by lymphopenia with lower numbers of CD3 + , CD3 + CD4 + , CD3 + CD8 + T lymphocyte, B lymphocyte, NK cell, and CD4/CD8 ratio. The evaluation of individual CD4/CD8 ratio should be combined with other clinical parameters. Conclusions: Patients with small cell lung cancer have altered lymphocyte homeostasis. Lymphopenia was a long-lasting feature of the enrolled patients who were treated with radiotherapy. The available lymphocyte subsets levels might be used to manage the clinical treatment scheme.
format	article
author	Hui Li MD Hong Yu MM Shaowei Lan MD Dandan Zhao MB Yan Liu MM Ying Cheng MB
author_facet	Hui Li MD Hong Yu MM Shaowei Lan MD Dandan Zhao MB Yan Liu MM Ying Cheng MB
author_sort	Hui Li MD
title	Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
title_short	Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
title_full	Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
title_fullStr	Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
title_full_unstemmed	Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
title_sort	aberrant alteration of circulating lymphocyte subsets in small cell lung cancer patients treated with radiotherapy
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/1e29bee7ae3a4d18a3743d9f71f1fd51
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Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy

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