Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.

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Autores principales:	Luca Ferrari, Riccardo Stucchi, Katerina Konstantoulea, Gerarda van de Kamp, Renate Kos, Willie J. C. Geerts, Laura S. van Bezouwen, Friedrich G. Förster, Maarten Altelaar, Casper C. Hoogenraad, Stefan G. D. Rüdiger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e2a4433b35f46b3b264a6a1c10869f9
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spelling	oai:doaj.org-article:1e2a4433b35f46b3b264a6a1c10869f92021-12-02T16:56:35ZArginine π-stacking drives binding to fibrils of the Alzheimer protein Tau10.1038/s41467-019-13745-72041-1723https://doaj.org/article/1e2a4433b35f46b3b264a6a1c10869f92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13745-7https://doaj.org/toc/2041-1723Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.Luca FerrariRiccardo StucchiKaterina KonstantouleaGerarda van de KampRenate KosWillie J. C. GeertsLaura S. van BezouwenFriedrich G. FörsterMaarten AltelaarCasper C. HoogenraadStefan G. D. RüdigerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luca Ferrari Riccardo Stucchi Katerina Konstantoulea Gerarda van de Kamp Renate Kos Willie J. C. Geerts Laura S. van Bezouwen Friedrich G. Förster Maarten Altelaar Casper C. Hoogenraad Stefan G. D. Rüdiger Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
description	Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.
format	article
author	Luca Ferrari Riccardo Stucchi Katerina Konstantoulea Gerarda van de Kamp Renate Kos Willie J. C. Geerts Laura S. van Bezouwen Friedrich G. Förster Maarten Altelaar Casper C. Hoogenraad Stefan G. D. Rüdiger
author_facet	Luca Ferrari Riccardo Stucchi Katerina Konstantoulea Gerarda van de Kamp Renate Kos Willie J. C. Geerts Laura S. van Bezouwen Friedrich G. Förster Maarten Altelaar Casper C. Hoogenraad Stefan G. D. Rüdiger
author_sort	Luca Ferrari
title	Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
title_short	Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
title_full	Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
title_fullStr	Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
title_full_unstemmed	Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
title_sort	arginine π-stacking drives binding to fibrils of the alzheimer protein tau
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1e2a4433b35f46b3b264a6a1c10869f9
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Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

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