A microRNA signature that correlates with cognition and is a target against cognitive decline
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causa...
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| Formato: | article |
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Wiley
2021
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| Acceso en línea: | https://doaj.org/article/1e2ab5f4a61e40db8cbade9a85f5dc94 |
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oai:doaj.org-article:1e2ab5f4a61e40db8cbade9a85f5dc942021-11-08T09:27:45ZA microRNA signature that correlates with cognition and is a target against cognitive decline1757-46841757-467610.15252/emmm.202013659https://doaj.org/article/1e2ab5f4a61e40db8cbade9a85f5dc942021-11-01T00:00:00Zhttps://doi.org/10.15252/emmm.202013659https://doaj.org/toc/1757-4676https://doaj.org/toc/1757-4684Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics.Md Rezaul IslamLalit KauraniTea BerulavaUrs HeilbronnerMonika BuddeTonatiuh Pena CentenoVakthang ElerdashviliMaria‐Patapia ZafieriouEva BenitoSinem M SertelMaria GoldbergFanny SennerJanos L KalmanSusanne BurkhardtAnne Sophie OepenMohammad Sadman SakibCemil KerimogluOliver WirthsHeike BickeböllerClaudia BartelsFrederic BrosseronKatharina BuergerNicoleta‐Carmen CosmaKlaus FliessbachMichael T. HenekaDaniel JanowitzIngo KilimannLuca KleinedamChristoph LaskeCoraline D MetzgerMatthias H MunkRobert PerneczkyOliver PetersJosef PrillerBoris S. RauchmannNina RoyAnja SchneiderAnnika SpottkeEike J SpruthStefan TeipelMaike TscheuschlerMichael WagnerJens WiltfangEmrah DüzelFrank JessenDelcode Study GroupSilvio O RizzoliWolfram‐Hubertus ZimmermannThomas G SchulzePeter FalkaiFarahnaz SananbenesiAndre FischerWileyarticleAlzheimerbiomarkercognitive impairmentmicroRNARNA therapeuticsMedicine (General)R5-920GeneticsQH426-470ENEMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Alzheimer biomarker cognitive impairment microRNA RNA therapeutics Medicine (General) R5-920 Genetics QH426-470 |
| spellingShingle |
Alzheimer biomarker cognitive impairment microRNA RNA therapeutics Medicine (General) R5-920 Genetics QH426-470 Md Rezaul Islam Lalit Kaurani Tea Berulava Urs Heilbronner Monika Budde Tonatiuh Pena Centeno Vakthang Elerdashvili Maria‐Patapia Zafieriou Eva Benito Sinem M Sertel Maria Goldberg Fanny Senner Janos L Kalman Susanne Burkhardt Anne Sophie Oepen Mohammad Sadman Sakib Cemil Kerimoglu Oliver Wirths Heike Bickeböller Claudia Bartels Frederic Brosseron Katharina Buerger Nicoleta‐Carmen Cosma Klaus Fliessbach Michael T. Heneka Daniel Janowitz Ingo Kilimann Luca Kleinedam Christoph Laske Coraline D Metzger Matthias H Munk Robert Perneczky Oliver Peters Josef Priller Boris S. Rauchmann Nina Roy Anja Schneider Annika Spottke Eike J Spruth Stefan Teipel Maike Tscheuschler Michael Wagner Jens Wiltfang Emrah Düzel Frank Jessen Delcode Study Group Silvio O Rizzoli Wolfram‐Hubertus Zimmermann Thomas G Schulze Peter Falkai Farahnaz Sananbenesi Andre Fischer A microRNA signature that correlates with cognition and is a target against cognitive decline |
| description |
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics. |
| format |
article |
| author |
Md Rezaul Islam Lalit Kaurani Tea Berulava Urs Heilbronner Monika Budde Tonatiuh Pena Centeno Vakthang Elerdashvili Maria‐Patapia Zafieriou Eva Benito Sinem M Sertel Maria Goldberg Fanny Senner Janos L Kalman Susanne Burkhardt Anne Sophie Oepen Mohammad Sadman Sakib Cemil Kerimoglu Oliver Wirths Heike Bickeböller Claudia Bartels Frederic Brosseron Katharina Buerger Nicoleta‐Carmen Cosma Klaus Fliessbach Michael T. Heneka Daniel Janowitz Ingo Kilimann Luca Kleinedam Christoph Laske Coraline D Metzger Matthias H Munk Robert Perneczky Oliver Peters Josef Priller Boris S. Rauchmann Nina Roy Anja Schneider Annika Spottke Eike J Spruth Stefan Teipel Maike Tscheuschler Michael Wagner Jens Wiltfang Emrah Düzel Frank Jessen Delcode Study Group Silvio O Rizzoli Wolfram‐Hubertus Zimmermann Thomas G Schulze Peter Falkai Farahnaz Sananbenesi Andre Fischer |
| author_facet |
Md Rezaul Islam Lalit Kaurani Tea Berulava Urs Heilbronner Monika Budde Tonatiuh Pena Centeno Vakthang Elerdashvili Maria‐Patapia Zafieriou Eva Benito Sinem M Sertel Maria Goldberg Fanny Senner Janos L Kalman Susanne Burkhardt Anne Sophie Oepen Mohammad Sadman Sakib Cemil Kerimoglu Oliver Wirths Heike Bickeböller Claudia Bartels Frederic Brosseron Katharina Buerger Nicoleta‐Carmen Cosma Klaus Fliessbach Michael T. Heneka Daniel Janowitz Ingo Kilimann Luca Kleinedam Christoph Laske Coraline D Metzger Matthias H Munk Robert Perneczky Oliver Peters Josef Priller Boris S. Rauchmann Nina Roy Anja Schneider Annika Spottke Eike J Spruth Stefan Teipel Maike Tscheuschler Michael Wagner Jens Wiltfang Emrah Düzel Frank Jessen Delcode Study Group Silvio O Rizzoli Wolfram‐Hubertus Zimmermann Thomas G Schulze Peter Falkai Farahnaz Sananbenesi Andre Fischer |
| author_sort |
Md Rezaul Islam |
| title |
A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_short |
A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_full |
A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_fullStr |
A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_full_unstemmed |
A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_sort |
microrna signature that correlates with cognition and is a target against cognitive decline |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/1e2ab5f4a61e40db8cbade9a85f5dc94 |
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