Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes

Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes

Lei Bao,* Xueting Chen,* Qingjie Li,* Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of...

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Autores principales: Bao L, Chen X, Li Q, Zhang R, Shi H, Cui G
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
guillain-barre syndrome
post-surgical gbs
surgery
electrophysiology
axonal neuropathy.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/1e2b4ad7e0494e3d9443a90e7bf3c61d
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spelling oai:doaj.org-article:1e2b4ad7e0494e3d9443a90e7bf3c61d2021-12-02T11:37:59ZSurgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes1178-2021https://doaj.org/article/1e2b4ad7e0494e3d9443a90e7bf3c61d2020-04-01T00:00:00Zhttps://www.dovepress.com/surgery-and-guillain-barreacute-syndrome-a-single-center-retrospective-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lei Bao,* Xueting Chen,* Qingjie Li,* Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of ChinaTel/Fax +86 516 85802129Email baolei56@gmail.comBackground: Surgery-related Guillain-Barré syndrome (GBS) is often underestimated and sometimes difficult to diagnose. This study aimed to elucidate the clinical features and electrophysiological subtypes of post-surgical GBS.Methods: We retrospectively reviewed 17 patients who developed post-surgical GBS after a recent surgery between 2015 and 2019. Clinical characteristics, electrophysiological examinations, lumbar puncture results and prognosis were assessed. As controls, we selected 66 patients hospitalized with non-surgical GBS.Results: The median duration from the surgery to the onset of GBS symptoms was 16.0 days. The main types of surgeries preceding GBS were orthopedic, gastrointestinal and neurosurgery. Symmetrical distal limbs weakness was present in all 17 post-surgical GBS patients. The incidence of respiratory failure, autonomic dysfunction and muscle atrophy in post-surgical GBS patients was significantly higher than that in non-surgical GBS patients. Hughes Functional Grading Scale (HFGS) scores were also higher in the post-surgical GBS group both at the time of peak disease and 6 months after discharge. Electrophysiological studies revealed significant motor amplitudes reduction with relative preserved nerve conduction velocities and distal latencies, suggesting axonal subtypes of GBS.Conclusion: GBS should be considered in patients with rapidly progressive muscle weakness after surgery. Such patients often exhibit axonal subtypes of GBS with severe motor dysfunction, high risk of respiratory failure, and poor prognosis.Keywords: Guillain-Barre syndrome, post-surgical GBS, surgery, electrophysiology, axonal neuropathyBao LChen XLi QZhang RShi HCui GDove Medical Pressarticleguillain-barre syndromepost-surgical gbssurgeryelectrophysiologyaxonal neuropathy.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 969-974 (2020)
institution DOAJ
collection DOAJ
language EN
topic guillain-barre syndrome
post-surgical gbs
surgery
electrophysiology
axonal neuropathy.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle guillain-barre syndrome
post-surgical gbs
surgery
electrophysiology
axonal neuropathy.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Bao L
Chen X
Li Q
Zhang R
Shi H
Cui G
Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes
description Lei Bao,* Xueting Chen,* Qingjie Li,* Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of ChinaTel/Fax +86 516 85802129Email baolei56@gmail.comBackground: Surgery-related Guillain-Barré syndrome (GBS) is often underestimated and sometimes difficult to diagnose. This study aimed to elucidate the clinical features and electrophysiological subtypes of post-surgical GBS.Methods: We retrospectively reviewed 17 patients who developed post-surgical GBS after a recent surgery between 2015 and 2019. Clinical characteristics, electrophysiological examinations, lumbar puncture results and prognosis were assessed. As controls, we selected 66 patients hospitalized with non-surgical GBS.Results: The median duration from the surgery to the onset of GBS symptoms was 16.0 days. The main types of surgeries preceding GBS were orthopedic, gastrointestinal and neurosurgery. Symmetrical distal limbs weakness was present in all 17 post-surgical GBS patients. The incidence of respiratory failure, autonomic dysfunction and muscle atrophy in post-surgical GBS patients was significantly higher than that in non-surgical GBS patients. Hughes Functional Grading Scale (HFGS) scores were also higher in the post-surgical GBS group both at the time of peak disease and 6 months after discharge. Electrophysiological studies revealed significant motor amplitudes reduction with relative preserved nerve conduction velocities and distal latencies, suggesting axonal subtypes of GBS.Conclusion: GBS should be considered in patients with rapidly progressive muscle weakness after surgery. Such patients often exhibit axonal subtypes of GBS with severe motor dysfunction, high risk of respiratory failure, and poor prognosis.Keywords: Guillain-Barre syndrome, post-surgical GBS, surgery, electrophysiology, axonal neuropathy
format article
author Bao L
Chen X
Li Q
Zhang R
Shi H
Cui G
author_facet Bao L
Chen X
Li Q
Zhang R
Shi H
Cui G
author_sort Bao L
title Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes
title_short Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes
title_full Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes
title_fullStr Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes
title_full_unstemmed Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes
title_sort surgery and guillain-barré syndrome: a single-center retrospective study focused on clinical and electrophysiological subtypes
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/1e2b4ad7e0494e3d9443a90e7bf3c61d
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