Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some aspects of sporadic late onset AD.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1e311a8bbdd34a96bb987b252f4dfaaf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1e311a8bbdd34a96bb987b252f4dfaaf2021-12-02T13:44:13ZGeneration of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology10.1038/s41467-021-22624-z2041-1723https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22624-zhttps://doaj.org/toc/2041-1723Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some aspects of sporadic late onset AD.David Baglietto-VargasStefania FornerLena CaiAlessandra C. MartiniLaura Trujillo-EstradaVivek SwarupMarie Minh Thu NguyenKelly Do HuynhDominic I. JavonilloKristine Minh TranJimmy PhanShan JiangEnikö A. KramárCristina Nuñez-DiazGabriela Balderrama-GutierrezFranklin GarciaJessica ChildsCarlos J. Rodriguez-OrtizJuan Antonio Garcia-LeonMasashi KitazawaMohammad ShahnawazDina P. MatheosXinyi MaCelia Da CunhaKen C. WallsRahasson R. AgerClaudio SotoAntonia GutierrezInes Moreno-GonzalezAli MortazaviAndrea J. TennerGrant R. MacGregorMarcelo WoodKim N. GreenFrank M. LaFerlaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David Baglietto-Vargas Stefania Forner Lena Cai Alessandra C. Martini Laura Trujillo-Estrada Vivek Swarup Marie Minh Thu Nguyen Kelly Do Huynh Dominic I. Javonillo Kristine Minh Tran Jimmy Phan Shan Jiang Enikö A. Kramár Cristina Nuñez-Diaz Gabriela Balderrama-Gutierrez Franklin Garcia Jessica Childs Carlos J. Rodriguez-Ortiz Juan Antonio Garcia-Leon Masashi Kitazawa Mohammad Shahnawaz Dina P. Matheos Xinyi Ma Celia Da Cunha Ken C. Walls Rahasson R. Ager Claudio Soto Antonia Gutierrez Ines Moreno-Gonzalez Ali Mortazavi Andrea J. Tenner Grant R. MacGregor Marcelo Wood Kim N. Green Frank M. LaFerla Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology |
| description |
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some aspects of sporadic late onset AD. |
| format |
article |
| author |
David Baglietto-Vargas Stefania Forner Lena Cai Alessandra C. Martini Laura Trujillo-Estrada Vivek Swarup Marie Minh Thu Nguyen Kelly Do Huynh Dominic I. Javonillo Kristine Minh Tran Jimmy Phan Shan Jiang Enikö A. Kramár Cristina Nuñez-Diaz Gabriela Balderrama-Gutierrez Franklin Garcia Jessica Childs Carlos J. Rodriguez-Ortiz Juan Antonio Garcia-Leon Masashi Kitazawa Mohammad Shahnawaz Dina P. Matheos Xinyi Ma Celia Da Cunha Ken C. Walls Rahasson R. Ager Claudio Soto Antonia Gutierrez Ines Moreno-Gonzalez Ali Mortazavi Andrea J. Tenner Grant R. MacGregor Marcelo Wood Kim N. Green Frank M. LaFerla |
| author_facet |
David Baglietto-Vargas Stefania Forner Lena Cai Alessandra C. Martini Laura Trujillo-Estrada Vivek Swarup Marie Minh Thu Nguyen Kelly Do Huynh Dominic I. Javonillo Kristine Minh Tran Jimmy Phan Shan Jiang Enikö A. Kramár Cristina Nuñez-Diaz Gabriela Balderrama-Gutierrez Franklin Garcia Jessica Childs Carlos J. Rodriguez-Ortiz Juan Antonio Garcia-Leon Masashi Kitazawa Mohammad Shahnawaz Dina P. Matheos Xinyi Ma Celia Da Cunha Ken C. Walls Rahasson R. Ager Claudio Soto Antonia Gutierrez Ines Moreno-Gonzalez Ali Mortazavi Andrea J. Tenner Grant R. MacGregor Marcelo Wood Kim N. Green Frank M. LaFerla |
| author_sort |
David Baglietto-Vargas |
| title |
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology |
| title_short |
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology |
| title_full |
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology |
| title_fullStr |
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology |
| title_full_unstemmed |
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology |
| title_sort |
generation of a humanized aβ expressing mouse demonstrating aspects of alzheimer’s disease-like pathology |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf |
| work_keys_str_mv |
AT davidbagliettovargas generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT stefaniaforner generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT lenacai generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT alessandracmartini generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT lauratrujilloestrada generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT vivekswarup generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT marieminhthunguyen generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT kellydohuynh generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT dominicijavonillo generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT kristineminhtran generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT jimmyphan generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT shanjiang generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT enikoakramar generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT cristinanunezdiaz generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT gabrielabalderramagutierrez generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT franklingarcia generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT jessicachilds generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT carlosjrodriguezortiz generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT juanantoniogarcialeon generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT masashikitazawa generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT mohammadshahnawaz generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT dinapmatheos generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT xinyima generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT celiadacunha generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT kencwalls generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT rahassonrager generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT claudiosoto generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT antoniagutierrez generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT inesmorenogonzalez generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT alimortazavi generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT andreajtenner generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT grantrmacgregor generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT marcelowood generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT kimngreen generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology AT frankmlaferla generationofahumanizedabexpressingmousedemonstratingaspectsofalzheimersdiseaselikepathology |
| _version_ |
1718392482097528832 |