Intravenous magnetic nanoparticle cancer hyperthermia

Hui S Huang, James F Hainfeld Nanoprobes, Yaphank, NY, USA Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huang HS, Hainfeld JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e322e7bcea74ce2ab585ad35f91406b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e322e7bcea74ce2ab585ad35f91406b
record_format	dspace
spelling	oai:doaj.org-article:1e322e7bcea74ce2ab585ad35f91406b2021-12-02T05:09:41ZIntravenous magnetic nanoparticle cancer hyperthermia1176-91141178-2013https://doaj.org/article/1e322e7bcea74ce2ab585ad35f91406b2013-07-01T00:00:00Zhttp://www.dovepress.com/intravenous-magnetic-nanoparticle-cancer-hyperthermia-a13684https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hui S Huang, James F Hainfeld Nanoprobes, Yaphank, NY, USA Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact. Keywords: magnetic nanoparticles, hyperthermia, cancer, alternating magnetic field, intravenous deliveryHuang HSHainfeld JFDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2521-2532 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Huang HS Hainfeld JF Intravenous magnetic nanoparticle cancer hyperthermia
description	Hui S Huang, James F Hainfeld Nanoprobes, Yaphank, NY, USA Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact. Keywords: magnetic nanoparticles, hyperthermia, cancer, alternating magnetic field, intravenous delivery
format	article
author	Huang HS Hainfeld JF
author_facet	Huang HS Hainfeld JF
author_sort	Huang HS
title	Intravenous magnetic nanoparticle cancer hyperthermia
title_short	Intravenous magnetic nanoparticle cancer hyperthermia
title_full	Intravenous magnetic nanoparticle cancer hyperthermia
title_fullStr	Intravenous magnetic nanoparticle cancer hyperthermia
title_full_unstemmed	Intravenous magnetic nanoparticle cancer hyperthermia
title_sort	intravenous magnetic nanoparticle cancer hyperthermia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/1e322e7bcea74ce2ab585ad35f91406b
work_keys_str_mv	AT huanghs intravenousmagneticnanoparticlecancerhyperthermia AT hainfeldjf intravenousmagneticnanoparticlecancerhyperthermia
_version_	1718400517893259264

Intravenous magnetic nanoparticle cancer hyperthermia

Ejemplares similares