Imbalanced dietary intake alters the colonic microbial profile in growing rats.

An imbalanced dietary intake is associated with alteration of intestinal ecosystem. We investigated the impact of imbalanced diets on colonic microbiota, concentrations of short chain fatty acid in colonic digesta and serum immunoglobulins (Igs) of growing rats. Compared to the control diet, consumi...

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Autores principales:	Tae-Hwan Jung, Kyoung-Sik Han
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e324e59323c427c8c0ca93d18977f16
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spelling	oai:doaj.org-article:1e324e59323c427c8c0ca93d18977f162021-12-02T20:15:42ZImbalanced dietary intake alters the colonic microbial profile in growing rats.1932-620310.1371/journal.pone.0253959https://doaj.org/article/1e324e59323c427c8c0ca93d18977f162021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253959https://doaj.org/toc/1932-6203An imbalanced dietary intake is associated with alteration of intestinal ecosystem. We investigated the impact of imbalanced diets on colonic microbiota, concentrations of short chain fatty acid in colonic digesta and serum immunoglobulins (Igs) of growing rats. Compared to the control diet, consuming diets high in fat, sucrose, or processed meat, or low in iron, increased the abundance of the pathogenic bacteria such as Clostridium, Escherichia coli, and Salmonella species, and decreased the beneficial bacteria, like Bifidobacteria, Lactobacillus, Akkermansia, Phascolarctobacterium, Alistipes, and butyrate producing species of bacteria in the colon of growing rats. The heatmap of metagenomics indicated that each group was separated into distinct clusters, and the ID group in particular, showed significantly (P < 0.01) reduced alpha diversity of colonic microbiota in comparison to the control group. All experimental groups showed significantly (P < 0.05 or P < 0.01) decreased concentration of acetate and butyrate in the colonic digesta and lower levels of serum IgG or IgA, compared to the control. These results indicated that the imbalanced dietary intake negatively altered intestinal ecosystem and immunity.Tae-Hwan JungKyoung-Sik HanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253959 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae-Hwan Jung Kyoung-Sik Han Imbalanced dietary intake alters the colonic microbial profile in growing rats.
description	An imbalanced dietary intake is associated with alteration of intestinal ecosystem. We investigated the impact of imbalanced diets on colonic microbiota, concentrations of short chain fatty acid in colonic digesta and serum immunoglobulins (Igs) of growing rats. Compared to the control diet, consuming diets high in fat, sucrose, or processed meat, or low in iron, increased the abundance of the pathogenic bacteria such as Clostridium, Escherichia coli, and Salmonella species, and decreased the beneficial bacteria, like Bifidobacteria, Lactobacillus, Akkermansia, Phascolarctobacterium, Alistipes, and butyrate producing species of bacteria in the colon of growing rats. The heatmap of metagenomics indicated that each group was separated into distinct clusters, and the ID group in particular, showed significantly (P < 0.01) reduced alpha diversity of colonic microbiota in comparison to the control group. All experimental groups showed significantly (P < 0.05 or P < 0.01) decreased concentration of acetate and butyrate in the colonic digesta and lower levels of serum IgG or IgA, compared to the control. These results indicated that the imbalanced dietary intake negatively altered intestinal ecosystem and immunity.
format	article
author	Tae-Hwan Jung Kyoung-Sik Han
author_facet	Tae-Hwan Jung Kyoung-Sik Han
author_sort	Tae-Hwan Jung
title	Imbalanced dietary intake alters the colonic microbial profile in growing rats.
title_short	Imbalanced dietary intake alters the colonic microbial profile in growing rats.
title_full	Imbalanced dietary intake alters the colonic microbial profile in growing rats.
title_fullStr	Imbalanced dietary intake alters the colonic microbial profile in growing rats.
title_full_unstemmed	Imbalanced dietary intake alters the colonic microbial profile in growing rats.
title_sort	imbalanced dietary intake alters the colonic microbial profile in growing rats.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1e324e59323c427c8c0ca93d18977f16
work_keys_str_mv	AT taehwanjung imbalanceddietaryintakealtersthecolonicmicrobialprofileingrowingrats AT kyoungsikhan imbalanceddietaryintakealtersthecolonicmicrobialprofileingrowingrats
_version_	1718374510551367680

Imbalanced dietary intake alters the colonic microbial profile in growing rats.

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