Plasma concentrations of zonulin are elevated in obese men with fatty liver disease

A-Sol Kim,1,2 Hae-Jin Ko1,3 1Department of Family Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea; 2Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu, South Korea; 3Department of Family Medicine, Kyungpook National University Hospita...

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Autores principales:	Kim AS, Ko HJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Zonulin Intestinal permeability Fatty liver Obesity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1e32a098f5124c2584e10b7810f7e847
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spelling	oai:doaj.org-article:1e32a098f5124c2584e10b7810f7e8472021-12-02T06:25:36ZPlasma concentrations of zonulin are elevated in obese men with fatty liver disease1178-7007https://doaj.org/article/1e32a098f5124c2584e10b7810f7e8472018-04-01T00:00:00Zhttps://www.dovepress.com/plasma-concentrations-of-zonulin-are-elevated-in-obese-men-with-fatty--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007A-Sol Kim,1,2 Hae-Jin Ko1,3 1Department of Family Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea; 2Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu, South Korea; 3Department of Family Medicine, Kyungpook National University Hospital, Daegu, South Korea Purpose: Zonulin is considered as a biomarker of increased intestinal permeability. The relationship between intestinal permeability and obesity is known, and many studies have investigated the relationship between intestinal permeability and liver disease. Thus, we aimed to investigate the potential association between plasma zonulin concentrations and fatty liver in obese men. Patients and methods: A total of 140 obese men without inflammatory bowel diseases, autoimmune diseases, and severe liver diseases were included. The subjects were divided into three groups: normal, mild fatty liver, and moderate-to-severe fatty liver, according to abdominal ultrasonography findings. We subdivided the subjects into two subgroups based on the amount of alcohol consumption (appropriate drinking and hazardous drinking), and subgroup analyses were performed. Results: The mean plasma zonulin concentrations (ng/mL) in the normal, mild fatty liver, and moderate-to-severe fatty liver groups were 0.618, 2.143, and 5.815, respectively (P<0.001). A multivariate multinomial logistic regression analysis revealed an odds ratio (OR) of 1.77 (P=0.015) in the moderate-to-severe fatty liver group. The median plasma zonulin concentrations (ng/mL) in the appropriate drinking subgroup of the fatty liver groups were 0.002, 0.500, and 6.550, respectively (P-trend<0.001), and in the hazardous drinking subgroup were 0.002, 0.590, and 5.800, respectively (P-trend=0.001). The ORs for moderate-to-severe fatty liver were 1.91 (P=0.039) in the appropriate drinking group and 1.56 (P=0.045) in the hazardous drinking group. Conclusion: Plasma zonulin concentrations were elevated among obese men. A significant association was found between zonulin concentrations and severity of fatty liver. Keywords: zonulin, intestinal permeability, fatty liver, obesityKim ASKo HJDove Medical PressarticleZonulinIntestinal permeabilityFatty liverObesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 149-157 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zonulin Intestinal permeability Fatty liver Obesity Specialties of internal medicine RC581-951
spellingShingle	Zonulin Intestinal permeability Fatty liver Obesity Specialties of internal medicine RC581-951 Kim AS Ko HJ Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
description	A-Sol Kim,1,2 Hae-Jin Ko1,3 1Department of Family Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea; 2Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu, South Korea; 3Department of Family Medicine, Kyungpook National University Hospital, Daegu, South Korea Purpose: Zonulin is considered as a biomarker of increased intestinal permeability. The relationship between intestinal permeability and obesity is known, and many studies have investigated the relationship between intestinal permeability and liver disease. Thus, we aimed to investigate the potential association between plasma zonulin concentrations and fatty liver in obese men. Patients and methods: A total of 140 obese men without inflammatory bowel diseases, autoimmune diseases, and severe liver diseases were included. The subjects were divided into three groups: normal, mild fatty liver, and moderate-to-severe fatty liver, according to abdominal ultrasonography findings. We subdivided the subjects into two subgroups based on the amount of alcohol consumption (appropriate drinking and hazardous drinking), and subgroup analyses were performed. Results: The mean plasma zonulin concentrations (ng/mL) in the normal, mild fatty liver, and moderate-to-severe fatty liver groups were 0.618, 2.143, and 5.815, respectively (P<0.001). A multivariate multinomial logistic regression analysis revealed an odds ratio (OR) of 1.77 (P=0.015) in the moderate-to-severe fatty liver group. The median plasma zonulin concentrations (ng/mL) in the appropriate drinking subgroup of the fatty liver groups were 0.002, 0.500, and 6.550, respectively (P-trend<0.001), and in the hazardous drinking subgroup were 0.002, 0.590, and 5.800, respectively (P-trend=0.001). The ORs for moderate-to-severe fatty liver were 1.91 (P=0.039) in the appropriate drinking group and 1.56 (P=0.045) in the hazardous drinking group. Conclusion: Plasma zonulin concentrations were elevated among obese men. A significant association was found between zonulin concentrations and severity of fatty liver. Keywords: zonulin, intestinal permeability, fatty liver, obesity
format	article
author	Kim AS Ko HJ
author_facet	Kim AS Ko HJ
author_sort	Kim AS
title	Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
title_short	Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
title_full	Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
title_fullStr	Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
title_full_unstemmed	Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
title_sort	plasma concentrations of zonulin are elevated in obese men with fatty liver disease
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1e32a098f5124c2584e10b7810f7e847
work_keys_str_mv	AT kimas plasmaconcentrationsofzonulinareelevatedinobesemenwithfattyliverdisease AT kohj plasmaconcentrationsofzonulinareelevatedinobesemenwithfattyliverdisease
_version_	1718399921016537088

Plasma concentrations of zonulin are elevated in obese men with fatty liver disease

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