MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of...

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Autores principales:	Delphine Lemaçon, Jessica Jackson, Annabel Quinet, Joshua R. Brickner, Shan Li, Stephanie Yazinski, Zhongsheng You, Grzegorz Ira, Lee Zou, Nima Mosammaparast, Alessandro Vindigni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e33c6e0d83d4e20804ca0da99f3189b
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spelling	oai:doaj.org-article:1e33c6e0d83d4e20804ca0da99f3189b2021-12-02T15:37:02ZMRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells10.1038/s41467-017-01180-52041-1723https://doaj.org/article/1e33c6e0d83d4e20804ca0da99f3189b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01180-5https://doaj.org/toc/2041-1723BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of genotoxic agent.Delphine LemaçonJessica JacksonAnnabel QuinetJoshua R. BricknerShan LiStephanie YazinskiZhongsheng YouGrzegorz IraLee ZouNima MosammaparastAlessandro VindigniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Delphine Lemaçon Jessica Jackson Annabel Quinet Joshua R. Brickner Shan Li Stephanie Yazinski Zhongsheng You Grzegorz Ira Lee Zou Nima Mosammaparast Alessandro Vindigni MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
description	BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of genotoxic agent.
format	article
author	Delphine Lemaçon Jessica Jackson Annabel Quinet Joshua R. Brickner Shan Li Stephanie Yazinski Zhongsheng You Grzegorz Ira Lee Zou Nima Mosammaparast Alessandro Vindigni
author_facet	Delphine Lemaçon Jessica Jackson Annabel Quinet Joshua R. Brickner Shan Li Stephanie Yazinski Zhongsheng You Grzegorz Ira Lee Zou Nima Mosammaparast Alessandro Vindigni
author_sort	Delphine Lemaçon
title	MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_short	MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_full	MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_fullStr	MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_full_unstemmed	MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_sort	mre11 and exo1 nucleases degrade reversed forks and elicit mus81-dependent fork rescue in brca2-deficient cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1e33c6e0d83d4e20804ca0da99f3189b
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MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

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