Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study
Chenyi Wang,1,2,* Qianglong Niu,1,* Haihong Lv,1,* Qian Li,1 Yuping Ma,1 Jiaojiao Tan,1 Chunhua Liu1 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of China; 2Department of Endocrinology, The First Clinical Medical College o...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1e33d3f2479c4557be0b0bc3ff4b810b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1e33d3f2479c4557be0b0bc3ff4b810b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1e33d3f2479c4557be0b0bc3ff4b810b2021-12-02T12:13:10ZElevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study1178-7007https://doaj.org/article/1e33d3f2479c4557be0b0bc3ff4b810b2020-11-01T00:00:00Zhttps://www.dovepress.com/elevated-tpoab-is-a-strong-predictor-of-autoimmune-development-in-pati-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Chenyi Wang,1,2,* Qianglong Niu,1,* Haihong Lv,1,* Qian Li,1 Yuping Ma,1 Jiaojiao Tan,1 Chunhua Liu1 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of China; 2Department of Endocrinology, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haihong Lv Department of EndocrinologyThe First Hospital of Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of ChinaEmail haihonglv@126.comObjective: The aim of this study was to assess the prevalence of thyroid autoimmunity in T2DM with NAFLD, furthermore explore the relationship between elevated TPOAb titer and the severity of NAFLD.Methods: A total of 400 patients with T2DM were divided into two groups according to NAFLD. Thyroid function and other metabolic indicators were measured.Results: There were more TPOAb-positive patients in both groups, and the prevalence of TPOAb positive was significantly different in two groups (17% vs 6.9%, p< 0.01). FT4 was significantly lower in patients with T2DM with NAFLD (median FT4 0.89 vs 1.08, p < 0.001), while TSH was increased (median TSH 2.85 vs 2.28, p < 0.05). In patients with T2DM with NAFLD, the proportion of women in the thyroid autoimmune-positive group was significantly higher than the negative (71.1% vs 46%, p < 0.01). Similarly, thyroid autoimmune-positive T2DM and NAFLD patients had lower FT4 levels (median FT4 0.59 vs 0.92, p < 0.001), higher TSH levels (median TSH 3.65 vs 2.67, p < 0.001), and much higher TPOAb/TGAb (median TPOAb/TGAb 6.8 vs 1.46, p < 0.001). The increase of TPOAb was significantly correlated with the severity of fatty liver. HbA1c, TC, TG, TSH, TPOAb/TGAb and severity of fatty liver were risk factors of thyroid autoimmunity.Conclusion: Autoimmune thyroid disease is more common in patients with T2DM complicated with NAFLD. Elevated TPOAb titer is closely related to fatty liver, suggesting that elevated TPOAb titer is a predictor of autoimmune development in T2DM with NAFLD.Keywords: type 2 diabetes mellitus, non-alcoholic fatty liver disease, thyroid peroxidase antibody, thyroglobulin antibody, autoimmune thyroid diseaseWang CNiu QLv HLi QMa YTan JLiu CDove Medical Pressarticletype 2 diabetes mellitusnon-alcoholic fatty liver diseasethyroid peroxidase antibodythyroglobulin antibodyautoimmune thyroid diseaseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4369-4378 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
type 2 diabetes mellitus non-alcoholic fatty liver disease thyroid peroxidase antibody thyroglobulin antibody autoimmune thyroid disease Specialties of internal medicine RC581-951 |
| spellingShingle |
type 2 diabetes mellitus non-alcoholic fatty liver disease thyroid peroxidase antibody thyroglobulin antibody autoimmune thyroid disease Specialties of internal medicine RC581-951 Wang C Niu Q Lv H Li Q Ma Y Tan J Liu C Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study |
| description |
Chenyi Wang,1,2,* Qianglong Niu,1,* Haihong Lv,1,* Qian Li,1 Yuping Ma,1 Jiaojiao Tan,1 Chunhua Liu1 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of China; 2Department of Endocrinology, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haihong Lv Department of EndocrinologyThe First Hospital of Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of ChinaEmail haihonglv@126.comObjective: The aim of this study was to assess the prevalence of thyroid autoimmunity in T2DM with NAFLD, furthermore explore the relationship between elevated TPOAb titer and the severity of NAFLD.Methods: A total of 400 patients with T2DM were divided into two groups according to NAFLD. Thyroid function and other metabolic indicators were measured.Results: There were more TPOAb-positive patients in both groups, and the prevalence of TPOAb positive was significantly different in two groups (17% vs 6.9%, p< 0.01). FT4 was significantly lower in patients with T2DM with NAFLD (median FT4 0.89 vs 1.08, p < 0.001), while TSH was increased (median TSH 2.85 vs 2.28, p < 0.05). In patients with T2DM with NAFLD, the proportion of women in the thyroid autoimmune-positive group was significantly higher than the negative (71.1% vs 46%, p < 0.01). Similarly, thyroid autoimmune-positive T2DM and NAFLD patients had lower FT4 levels (median FT4 0.59 vs 0.92, p < 0.001), higher TSH levels (median TSH 3.65 vs 2.67, p < 0.001), and much higher TPOAb/TGAb (median TPOAb/TGAb 6.8 vs 1.46, p < 0.001). The increase of TPOAb was significantly correlated with the severity of fatty liver. HbA1c, TC, TG, TSH, TPOAb/TGAb and severity of fatty liver were risk factors of thyroid autoimmunity.Conclusion: Autoimmune thyroid disease is more common in patients with T2DM complicated with NAFLD. Elevated TPOAb titer is closely related to fatty liver, suggesting that elevated TPOAb titer is a predictor of autoimmune development in T2DM with NAFLD.Keywords: type 2 diabetes mellitus, non-alcoholic fatty liver disease, thyroid peroxidase antibody, thyroglobulin antibody, autoimmune thyroid disease |
| format |
article |
| author |
Wang C Niu Q Lv H Li Q Ma Y Tan J Liu C |
| author_facet |
Wang C Niu Q Lv H Li Q Ma Y Tan J Liu C |
| author_sort |
Wang C |
| title |
Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study |
| title_short |
Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study |
| title_full |
Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study |
| title_fullStr |
Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study |
| title_full_unstemmed |
Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study |
| title_sort |
elevated tpoab is a strong predictor of autoimmune development in patients of type 2 diabetes mellitus and non-alcoholic fatty liver disease: a case–control study |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/1e33d3f2479c4557be0b0bc3ff4b810b |
| work_keys_str_mv |
AT wangc elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy AT niuq elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy AT lvh elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy AT liq elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy AT may elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy AT tanj elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy AT liuc elevatedtpoabisastrongpredictorofautoimmunedevelopmentinpatientsoftype2diabetesmellitusandnonalcoholicfattyliverdiseaseacasendashcontrolstudy |
| _version_ |
1718394558954340352 |