Anatomical correlates of cognitive functions in early Parkinson's disease patients.

<h4>Background</h4>Cognitive deficits may occur early in Parkinson's disease (PD) but the extent of cortical involvement associated with cognitive dysfunction needs additional investigations. The aim of our study is to identify the anatomical pattern of cortical thickness alteration...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Roberta Biundo, Massimiliano Calabrese, Luca Weis, Silvia Facchini, Gianluigi Ricchieri, Paolo Gallo, Angelo Antonini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e37875e9ae3438d98682efa71e89821
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e37875e9ae3438d98682efa71e89821
record_format	dspace
spelling	oai:doaj.org-article:1e37875e9ae3438d98682efa71e898212021-11-18T07:44:35ZAnatomical correlates of cognitive functions in early Parkinson's disease patients.1932-620310.1371/journal.pone.0064222https://doaj.org/article/1e37875e9ae3438d98682efa71e898212013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717572/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cognitive deficits may occur early in Parkinson's disease (PD) but the extent of cortical involvement associated with cognitive dysfunction needs additional investigations. The aim of our study is to identify the anatomical pattern of cortical thickness alterations in patients with early stage PD and its relationship with cognitive disability.<h4>Methods</h4>We recruited 29 PD patients and 21 healthy controls. All PD patients performed an extensive neuropsychological examination and 14 were diagnosed with mild cognitive impairment (PD-MCI). Surface-based cortical thickness analysis was applied to investigate the topographical distribution of cortical and subcortical alterations in early PD compared with controls and to assess the relationship between cognition and regional cortical changes in PD-MCI.<h4>Results</h4>Overall PD patients showed focal cortical (occipital-parietal areas, orbito-frontal and olfactory areas) and subcortical thinning when compared with controls. PD-MCI showed a wide spectrum of cognitive deficits and related significant regional thickening in the right parietal-frontal as well as in the left temporal-occipital areas.<h4>Conclusion</h4>Our results confirm the presence of changes in grey matter thickness at relatively early PD stage and support previous studies showing thinning and atrophy in the neocortex and subcortical regions. Relative cortical thickening in PD-MCI may instead express compensatory neuroplasticity. Brain reserve mechanisms might first modulate cognitive decline during the initial stages of PD.Roberta BiundoMassimiliano CalabreseLuca WeisSilvia FacchiniGianluigi RicchieriPaolo GalloAngelo AntoniniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64222 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roberta Biundo Massimiliano Calabrese Luca Weis Silvia Facchini Gianluigi Ricchieri Paolo Gallo Angelo Antonini Anatomical correlates of cognitive functions in early Parkinson's disease patients.
description	<h4>Background</h4>Cognitive deficits may occur early in Parkinson's disease (PD) but the extent of cortical involvement associated with cognitive dysfunction needs additional investigations. The aim of our study is to identify the anatomical pattern of cortical thickness alterations in patients with early stage PD and its relationship with cognitive disability.<h4>Methods</h4>We recruited 29 PD patients and 21 healthy controls. All PD patients performed an extensive neuropsychological examination and 14 were diagnosed with mild cognitive impairment (PD-MCI). Surface-based cortical thickness analysis was applied to investigate the topographical distribution of cortical and subcortical alterations in early PD compared with controls and to assess the relationship between cognition and regional cortical changes in PD-MCI.<h4>Results</h4>Overall PD patients showed focal cortical (occipital-parietal areas, orbito-frontal and olfactory areas) and subcortical thinning when compared with controls. PD-MCI showed a wide spectrum of cognitive deficits and related significant regional thickening in the right parietal-frontal as well as in the left temporal-occipital areas.<h4>Conclusion</h4>Our results confirm the presence of changes in grey matter thickness at relatively early PD stage and support previous studies showing thinning and atrophy in the neocortex and subcortical regions. Relative cortical thickening in PD-MCI may instead express compensatory neuroplasticity. Brain reserve mechanisms might first modulate cognitive decline during the initial stages of PD.
format	article
author	Roberta Biundo Massimiliano Calabrese Luca Weis Silvia Facchini Gianluigi Ricchieri Paolo Gallo Angelo Antonini
author_facet	Roberta Biundo Massimiliano Calabrese Luca Weis Silvia Facchini Gianluigi Ricchieri Paolo Gallo Angelo Antonini
author_sort	Roberta Biundo
title	Anatomical correlates of cognitive functions in early Parkinson's disease patients.
title_short	Anatomical correlates of cognitive functions in early Parkinson's disease patients.
title_full	Anatomical correlates of cognitive functions in early Parkinson's disease patients.
title_fullStr	Anatomical correlates of cognitive functions in early Parkinson's disease patients.
title_full_unstemmed	Anatomical correlates of cognitive functions in early Parkinson's disease patients.
title_sort	anatomical correlates of cognitive functions in early parkinson's disease patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1e37875e9ae3438d98682efa71e89821
work_keys_str_mv	AT robertabiundo anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients AT massimilianocalabrese anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients AT lucaweis anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients AT silviafacchini anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients AT gianluigiricchieri anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients AT paologallo anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients AT angeloantonini anatomicalcorrelatesofcognitivefunctionsinearlyparkinsonsdiseasepatients
_version_	1718423019797348352

Anatomical correlates of cognitive functions in early Parkinson's disease patients.

Ejemplares similares