Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage perio...

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Autores principales:	Abu Abed Omar S., Mulkala Srilikha, Sharif Israa, Abdin Asma M., Elkordy Amal A.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	liposomes proliposomes lipid delivery systems cinnarizine oral delivery Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/1e386e7779cc4558bd451ea3b3f6d64d
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spelling	oai:doaj.org-article:1e386e7779cc4558bd451ea3b3f6d64d2021-12-05T14:11:02ZLyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study2365-24112365-242X10.1515/pthp-2021-0002https://doaj.org/article/1e386e7779cc4558bd451ea3b3f6d64d2021-05-01T00:00:00Zhttps://doi.org/10.1515/pthp-2021-0002https://doaj.org/toc/2365-2411https://doaj.org/toc/2365-242XCinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics.Abu Abed Omar S.Mulkala SrilikhaSharif IsraaAbdin Asma M.Elkordy Amal A.De Gruyterarticleliposomesproliposomeslipid delivery systemscinnarizineoral deliveryTherapeutics. PharmacologyRM1-950Pharmaceutical industryHD9665-9675ENPharmaceutical Technology in Hospital Pharmacy, Vol 6, Iss 1, Pp e1067-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liposomes proliposomes lipid delivery systems cinnarizine oral delivery Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675
spellingShingle	liposomes proliposomes lipid delivery systems cinnarizine oral delivery Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675 Abu Abed Omar S. Mulkala Srilikha Sharif Israa Abdin Asma M. Elkordy Amal A. Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
description	Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics.
format	article
author	Abu Abed Omar S. Mulkala Srilikha Sharif Israa Abdin Asma M. Elkordy Amal A.
author_facet	Abu Abed Omar S. Mulkala Srilikha Sharif Israa Abdin Asma M. Elkordy Amal A.
author_sort	Abu Abed Omar S.
title	Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_short	Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_full	Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_fullStr	Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_full_unstemmed	Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_sort	lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/1e386e7779cc4558bd451ea3b3f6d64d
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Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

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