A Dynamical Model for Activating and Silencing the Mitotic Checkpoint

Abstract The spindle assembly checkpoint (SAC) is an evolutionarily conserved mechanism, exclusively sensitive to the states of kinetochores attached to microtubules. During metaphase, the anaphase-promoting complex/cyclosome (APC/C) is inhibited by the SAC but it rapidly switches to its active form...

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Autores principales: Richard Henze, Peter Dittrich, Bashar Ibrahim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1e398d11714a4dff9be9da11317f6f28
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