USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

BRCA1 ligase activity is tightly regulated to maintain genome stability and confer DNA double strand repair. Here the authors identify USP48 as a H2A deubiquitinating enzyme that acts as a BRCA1 E3 ligase antagonist and characterize its role during DNA repair.

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Autores principales:	Michael Uckelmann, Ruth M. Densham, Roy Baas, Herrie H. K. Winterwerp, Alexander Fish, Titia K. Sixma, Joanna R. Morris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e3a338b35724ff5b4dbc88530cac69f
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spelling	oai:doaj.org-article:1e3a338b35724ff5b4dbc88530cac69f2021-12-02T16:56:37ZUSP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A10.1038/s41467-017-02653-32041-1723https://doaj.org/article/1e3a338b35724ff5b4dbc88530cac69f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02653-3https://doaj.org/toc/2041-1723BRCA1 ligase activity is tightly regulated to maintain genome stability and confer DNA double strand repair. Here the authors identify USP48 as a H2A deubiquitinating enzyme that acts as a BRCA1 E3 ligase antagonist and characterize its role during DNA repair.Michael UckelmannRuth M. DenshamRoy BaasHerrie H. K. WinterwerpAlexander FishTitia K. SixmaJoanna R. MorrisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Uckelmann Ruth M. Densham Roy Baas Herrie H. K. Winterwerp Alexander Fish Titia K. Sixma Joanna R. Morris USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
description	BRCA1 ligase activity is tightly regulated to maintain genome stability and confer DNA double strand repair. Here the authors identify USP48 as a H2A deubiquitinating enzyme that acts as a BRCA1 E3 ligase antagonist and characterize its role during DNA repair.
format	article
author	Michael Uckelmann Ruth M. Densham Roy Baas Herrie H. K. Winterwerp Alexander Fish Titia K. Sixma Joanna R. Morris
author_facet	Michael Uckelmann Ruth M. Densham Roy Baas Herrie H. K. Winterwerp Alexander Fish Titia K. Sixma Joanna R. Morris
author_sort	Michael Uckelmann
title	USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
title_short	USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
title_full	USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
title_fullStr	USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
title_full_unstemmed	USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
title_sort	usp48 restrains resection by site-specific cleavage of the brca1 ubiquitin mark from h2a
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1e3a338b35724ff5b4dbc88530cac69f
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USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

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