Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis

Tuberculosis necrotizing toxin (TNT) is secreted by Mycobacterium tuberculosis to kill host cells. Here, Tak, Dokland and Niederweis show that proteins EsxE and EsxF form membrane-spanning hetero-oligomeric pores that are important for TNT secretion.

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Autores principales:	Uday Tak, Terje Dokland, Michael Niederweis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e3b681c61014243b9c8f3663749dc0e
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spelling	oai:doaj.org-article:1e3b681c61014243b9c8f3663749dc0e2021-12-02T14:11:45ZPore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis10.1038/s41467-020-20533-12041-1723https://doaj.org/article/1e3b681c61014243b9c8f3663749dc0e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20533-1https://doaj.org/toc/2041-1723Tuberculosis necrotizing toxin (TNT) is secreted by Mycobacterium tuberculosis to kill host cells. Here, Tak, Dokland and Niederweis show that proteins EsxE and EsxF form membrane-spanning hetero-oligomeric pores that are important for TNT secretion.Uday TakTerje DoklandMichael NiederweisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Uday Tak Terje Dokland Michael Niederweis Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
description	Tuberculosis necrotizing toxin (TNT) is secreted by Mycobacterium tuberculosis to kill host cells. Here, Tak, Dokland and Niederweis show that proteins EsxE and EsxF form membrane-spanning hetero-oligomeric pores that are important for TNT secretion.
format	article
author	Uday Tak Terje Dokland Michael Niederweis
author_facet	Uday Tak Terje Dokland Michael Niederweis
author_sort	Uday Tak
title	Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
title_short	Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
title_full	Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
title_fullStr	Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
title_full_unstemmed	Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
title_sort	pore-forming esx proteins mediate toxin secretion by mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1e3b681c61014243b9c8f3663749dc0e
work_keys_str_mv	AT udaytak poreformingesxproteinsmediatetoxinsecretionbymycobacteriumtuberculosis AT terjedokland poreformingesxproteinsmediatetoxinsecretionbymycobacteriumtuberculosis AT michaelniederweis poreformingesxproteinsmediatetoxinsecretionbymycobacteriumtuberculosis
_version_	1718391830100312064

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis

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