Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy

Abstract Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demons...

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Autores principales:	Sweejiang Yoo, Jin Hou, Wenhui Yi, Yingchun Li, Weiping Chen, Lingjie Meng, Jinhai Si, Xun Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e3c65ced48f43aa9bb7262526360548
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spelling	oai:doaj.org-article:1e3c65ced48f43aa9bb72625263605482021-12-02T15:05:57ZEnhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy10.1038/s41598-017-01118-32045-2322https://doaj.org/article/1e3c65ced48f43aa9bb72625263605482017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01118-3https://doaj.org/toc/2045-2322Abstract Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demonstrated that metformin loaded on carbon nanotubes under near-infrared (NIR) irradiation led to the remarkably enhancement in response towards cancer cells. The dose of metformin has reduced to only 1/280 of typical doses in monotherapy (35: 10 000–30 000 µM) where the realization of metformin in conventional antidiabetic doses for cancer therapies becomes possible. The heat generated from carbon nanotubes upon NIR irradiation has mediated a strong and highly localized hyperthermia-like condition that facilitated the enhancement. Our work highlight the promise of using highly localized heating from carbon nanotubes to intensify the efficacy of metformin for potential cancer therapies.Sweejiang YooJin HouWenhui YiYingchun LiWeiping ChenLingjie MengJinhai SiXun HouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sweejiang Yoo Jin Hou Wenhui Yi Yingchun Li Weiping Chen Lingjie Meng Jinhai Si Xun Hou Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy
description	Abstract Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demonstrated that metformin loaded on carbon nanotubes under near-infrared (NIR) irradiation led to the remarkably enhancement in response towards cancer cells. The dose of metformin has reduced to only 1/280 of typical doses in monotherapy (35: 10 000–30 000 µM) where the realization of metformin in conventional antidiabetic doses for cancer therapies becomes possible. The heat generated from carbon nanotubes upon NIR irradiation has mediated a strong and highly localized hyperthermia-like condition that facilitated the enhancement. Our work highlight the promise of using highly localized heating from carbon nanotubes to intensify the efficacy of metformin for potential cancer therapies.
format	article
author	Sweejiang Yoo Jin Hou Wenhui Yi Yingchun Li Weiping Chen Lingjie Meng Jinhai Si Xun Hou
author_facet	Sweejiang Yoo Jin Hou Wenhui Yi Yingchun Li Weiping Chen Lingjie Meng Jinhai Si Xun Hou
author_sort	Sweejiang Yoo
title	Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy
title_short	Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy
title_full	Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy
title_fullStr	Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy
title_full_unstemmed	Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy
title_sort	enhanced response of metformin towards the cancer cells due to synergism with multi-walled carbon nanotubes in photothermal therapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1e3c65ced48f43aa9bb7262526360548
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Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy

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