Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas

Antonio Cano-Ortiz,1 Pablo Morales,2 Álvaro Sánchez-Ventosa,1 Isabel Leiva-Gea,3,4 Alberto Membrillo,1,5 Vasyl Druchkiv,6,7 Timoteo González-Cruces,1 José-María Sánchez-González,8 Jaime Beltrán,7 Alberto Villarrubia1 1Instituto de Oftalmología la Arruzafa, Córdoba, Spain; 2Department of Cataract and...

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Autores principales:	Cano-Ortiz A, Morales P, Sánchez-Ventosa, Leiva-Gea I, Membrillo A, Druchkiv V, González-Cruces T, Sánchez-González JM, Beltrán J, Villarrubia A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	topography-guided phototerapeutic keratectomy irregular astigmatism. laser refractive surgery mitomycin c Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1e3f2c36d04845999e82dfcb208c99fe
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spelling	oai:doaj.org-article:1e3f2c36d04845999e82dfcb208c99fe2021-12-02T14:56:22ZAberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas1177-5483https://doaj.org/article/1e3f2c36d04845999e82dfcb208c99fe2021-09-01T00:00:00Zhttps://www.dovepress.com/aberrometric-keratometric-and-visual-outcomes-after-trans-epithelial-t-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Antonio Cano-Ortiz,1 Pablo Morales,2 Álvaro Sánchez-Ventosa,1 Isabel Leiva-Gea,3,4 Alberto Membrillo,1,5 Vasyl Druchkiv,6,7 Timoteo González-Cruces,1 José-María Sánchez-González,8 Jaime Beltrán,7 Alberto Villarrubia1 1Instituto de Oftalmología la Arruzafa, Córdoba, Spain; 2Department of Cataract and Refractive Surgery, Clínica Baviera, Málaga, Spain; 3Hospital Regional Universitario de Málaga, Málaga, Spain; 4Istituto de Biomedicina de Málaga (IBIMA), Málaga, Spain; 5Universidad de Córdoba, Córdoba, Spain; 6University Medical Center Hamburg Eppendorf, Hamburg, Germany; 7Department of Research & Development, Clínica Baviera, Valencia, Spain; 8Department of Physics of Condensed Matter, Optics Area University of Seville, Seville, SpainCorrespondence: Pablo Morales; Isabel Leiva-Gea Málaga, SpainTel +34 669 232 767; Tel +34 677254051Email pblmorales@hotmail.com; isabeleiva@hotmail.comPurpose: To assess the safety, aberrometric and keratometric changes, and stability of trans-epithelial topography-guided phototherapeutic keratectomy (TE-TG-PTK) with mitomycin C (MMC) using the ALLEGRO Topolyzer platform for the treatment of irregular astigmatism.Methods: This is a retrospective case series including 57 eyes that underwent TE-TG-PTK + MMC using the ALLEGRO Topolyzer platform for the treatment of irregular astigmatism. CDVA, manifest refraction (MR), keratometry readings, and aberrometry readings were analyzed at 1, 3, 6, and 12 months.Results: Causes of corneal irregularity included non-infectious leucoma (n=23), infectious leucoma (n=7), adenoviral keratitis (n=20), corneal haze (n=2), post-penetrant keratoplasty (PKP) (n=1), and others (n=4). Overall, 76% of the eyes (n=40) gained lines of vision; patients gained 1, and 2 or more lines of vision in 76%, and 38% of cases, respectively. Only 1 patient (2%) lost 5 lines of vision. Mean preoperative CDVA (LogMAR) was 0.37 ± 0.31 and improved to 0.14 ± 0.18 (p< 0.001) at final follow-up (12 months). CDVA remained unchanged in 10 eyes (21%). No significant changes were observed in mean keratometry (Kmean) and keratometric astigmatism readings. Regarding aberrometry, only changes in coma proved to be significant 6 months after surgery (P< 0.01). No intraoperative/postoperative complications were reported.Conclusion: At final follow-up, significant improvements were observed in CDVA and coma. TE-TG-PTK + MMC proved to be an effective and safe procedure for the treatment of corneal irregular astigmatism due to several causes.Keywords: topography-guided phototherapeutic keratectomy, irregular astigmatism. laser refractive surgery, mitomycin CCano-Ortiz AMorales PSánchez-VentosaLeiva-Gea IMembrillo ADruchkiv VGonzález-Cruces TSánchez-González JMBeltrán JVillarrubia ADove Medical Pressarticletopography-guided phototerapeutic keratectomyirregular astigmatism. laser refractive surgerymitomycin cOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3777-3786 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	topography-guided phototerapeutic keratectomy irregular astigmatism. laser refractive surgery mitomycin c Ophthalmology RE1-994
spellingShingle	topography-guided phototerapeutic keratectomy irregular astigmatism. laser refractive surgery mitomycin c Ophthalmology RE1-994 Cano-Ortiz A Morales P Sánchez-Ventosa Leiva-Gea I Membrillo A Druchkiv V González-Cruces T Sánchez-González JM Beltrán J Villarrubia A Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas
description	Antonio Cano-Ortiz,1 Pablo Morales,2 Álvaro Sánchez-Ventosa,1 Isabel Leiva-Gea,3,4 Alberto Membrillo,1,5 Vasyl Druchkiv,6,7 Timoteo González-Cruces,1 José-María Sánchez-González,8 Jaime Beltrán,7 Alberto Villarrubia1 1Instituto de Oftalmología la Arruzafa, Córdoba, Spain; 2Department of Cataract and Refractive Surgery, Clínica Baviera, Málaga, Spain; 3Hospital Regional Universitario de Málaga, Málaga, Spain; 4Istituto de Biomedicina de Málaga (IBIMA), Málaga, Spain; 5Universidad de Córdoba, Córdoba, Spain; 6University Medical Center Hamburg Eppendorf, Hamburg, Germany; 7Department of Research & Development, Clínica Baviera, Valencia, Spain; 8Department of Physics of Condensed Matter, Optics Area University of Seville, Seville, SpainCorrespondence: Pablo Morales; Isabel Leiva-Gea Málaga, SpainTel +34 669 232 767; Tel +34 677254051Email pblmorales@hotmail.com; isabeleiva@hotmail.comPurpose: To assess the safety, aberrometric and keratometric changes, and stability of trans-epithelial topography-guided phototherapeutic keratectomy (TE-TG-PTK) with mitomycin C (MMC) using the ALLEGRO Topolyzer platform for the treatment of irregular astigmatism.Methods: This is a retrospective case series including 57 eyes that underwent TE-TG-PTK + MMC using the ALLEGRO Topolyzer platform for the treatment of irregular astigmatism. CDVA, manifest refraction (MR), keratometry readings, and aberrometry readings were analyzed at 1, 3, 6, and 12 months.Results: Causes of corneal irregularity included non-infectious leucoma (n=23), infectious leucoma (n=7), adenoviral keratitis (n=20), corneal haze (n=2), post-penetrant keratoplasty (PKP) (n=1), and others (n=4). Overall, 76% of the eyes (n=40) gained lines of vision; patients gained 1, and 2 or more lines of vision in 76%, and 38% of cases, respectively. Only 1 patient (2%) lost 5 lines of vision. Mean preoperative CDVA (LogMAR) was 0.37 ± 0.31 and improved to 0.14 ± 0.18 (p< 0.001) at final follow-up (12 months). CDVA remained unchanged in 10 eyes (21%). No significant changes were observed in mean keratometry (Kmean) and keratometric astigmatism readings. Regarding aberrometry, only changes in coma proved to be significant 6 months after surgery (P< 0.01). No intraoperative/postoperative complications were reported.Conclusion: At final follow-up, significant improvements were observed in CDVA and coma. TE-TG-PTK + MMC proved to be an effective and safe procedure for the treatment of corneal irregular astigmatism due to several causes.Keywords: topography-guided phototherapeutic keratectomy, irregular astigmatism. laser refractive surgery, mitomycin C
format	article
author	Cano-Ortiz A Morales P Sánchez-Ventosa Leiva-Gea I Membrillo A Druchkiv V González-Cruces T Sánchez-González JM Beltrán J Villarrubia A
author_facet	Cano-Ortiz A Morales P Sánchez-Ventosa Leiva-Gea I Membrillo A Druchkiv V González-Cruces T Sánchez-González JM Beltrán J Villarrubia A
author_sort	Cano-Ortiz A
title	Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas
title_short	Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas
title_full	Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas
title_fullStr	Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas
title_full_unstemmed	Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas
title_sort	aberrometric, keratometric, and visual outcomes after trans-epithelial topography-guided phototherapeutic keratectomy for the treatment of irregular corneas
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1e3f2c36d04845999e82dfcb208c99fe
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Aberrometric, Keratometric, and Visual Outcomes After Trans-Epithelial Topography-Guided Phototherapeutic Keratectomy for the Treatment of Irregular Corneas

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