An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting...

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Autores principales:	Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y.C. Lai, Christopher L. O’Connor, YiFan Wu, Jeffrey B. Hodgin, Robert G. Nelson, Markus Bitzer, Rama Natarajan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e41366d4ecd419690836c365275caed
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spelling	oai:doaj.org-article:1e41366d4ecd419690836c365275caed2021-12-02T17:31:32ZAn endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy10.1038/ncomms128642041-1723https://doaj.org/article/1e41366d4ecd419690836c365275caed2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12864https://doaj.org/toc/2041-1723Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting a new therapy for diabetic nephropathy.Mitsuo KatoMei WangZhuo ChenKirti BhattHyung Jung OhLinda LantingSupriya DeshpandeYe JiaJennifer Y.C. LaiChristopher L. O’ConnorYiFan WuJeffrey B. HodginRobert G. NelsonMarkus BitzerRama NatarajanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mitsuo Kato Mei Wang Zhuo Chen Kirti Bhatt Hyung Jung Oh Linda Lanting Supriya Deshpande Ye Jia Jennifer Y.C. Lai Christopher L. O’Connor YiFan Wu Jeffrey B. Hodgin Robert G. Nelson Markus Bitzer Rama Natarajan An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy
description	Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting a new therapy for diabetic nephropathy.
format	article
author	Mitsuo Kato Mei Wang Zhuo Chen Kirti Bhatt Hyung Jung Oh Linda Lanting Supriya Deshpande Ye Jia Jennifer Y.C. Lai Christopher L. O’Connor YiFan Wu Jeffrey B. Hodgin Robert G. Nelson Markus Bitzer Rama Natarajan
author_facet	Mitsuo Kato Mei Wang Zhuo Chen Kirti Bhatt Hyung Jung Oh Linda Lanting Supriya Deshpande Ye Jia Jennifer Y.C. Lai Christopher L. O’Connor YiFan Wu Jeffrey B. Hodgin Robert G. Nelson Markus Bitzer Rama Natarajan
author_sort	Mitsuo Kato
title	An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy
title_short	An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy
title_full	An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy
title_fullStr	An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy
title_full_unstemmed	An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy
title_sort	endoplasmic reticulum stress-regulated lncrna hosting a microrna megacluster induces early features of diabetic nephropathy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1e41366d4ecd419690836c365275caed
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An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

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