A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach

Abstract Plant derived products have steadily gained momentum in treatment of cancer over the past decades. Curcuma and its derivatives, in particular, have diverse medicinal properties including anticancer potential with proven safety as supported by numerous in vivo and in vitro studies. A defecti...

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Autores principales:	Priyanjali Bhattacharya, Trupti N. Patel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e416b8bc74e4e0295540cfa5f212a9f
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spelling	oai:doaj.org-article:1e416b8bc74e4e0295540cfa5f212a9f2021-12-02T17:16:06ZA study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach10.1038/s41598-021-89282-52045-2322https://doaj.org/article/1e416b8bc74e4e0295540cfa5f212a9f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89282-5https://doaj.org/toc/2045-2322Abstract Plant derived products have steadily gained momentum in treatment of cancer over the past decades. Curcuma and its derivatives, in particular, have diverse medicinal properties including anticancer potential with proven safety as supported by numerous in vivo and in vitro studies. A defective Mis-Match Repair (MMR) is implicated in solid tumors but its role in haematologic malignancies is not keenly studied and the current literature suggests that it is limited. Nonetheless, there are multiple pathways interjecting the mismatch repair proteins in haematologic cancers that may have a direct or indirect implication in progression of the disease. Here, through computational analysis, we target proteins that are involved in rewiring of multiple signaling cascades via altered expression in cancer using various curcuma derivatives (Curcuma longa L. and Curcuma caesia Roxb.) which in turn, profoundly controls MMR protein function. These biomolecules were screened to identify their efficacy on selected targets (in blood-related cancers); aberrations of which adversely impacted mismatch repair machinery. The study revealed that of the 536 compounds screened, six of them may have the potential to regulate the expression of identified targets and thus revive the MMR function preventing genomic instability. These results reveal that there may be potential plant derived biomolecules that may have anticancer properties against the tumors driven by deregulated MMR-pathways.Priyanjali BhattacharyaTrupti N. PatelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Priyanjali Bhattacharya Trupti N. Patel A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach
description	Abstract Plant derived products have steadily gained momentum in treatment of cancer over the past decades. Curcuma and its derivatives, in particular, have diverse medicinal properties including anticancer potential with proven safety as supported by numerous in vivo and in vitro studies. A defective Mis-Match Repair (MMR) is implicated in solid tumors but its role in haematologic malignancies is not keenly studied and the current literature suggests that it is limited. Nonetheless, there are multiple pathways interjecting the mismatch repair proteins in haematologic cancers that may have a direct or indirect implication in progression of the disease. Here, through computational analysis, we target proteins that are involved in rewiring of multiple signaling cascades via altered expression in cancer using various curcuma derivatives (Curcuma longa L. and Curcuma caesia Roxb.) which in turn, profoundly controls MMR protein function. These biomolecules were screened to identify their efficacy on selected targets (in blood-related cancers); aberrations of which adversely impacted mismatch repair machinery. The study revealed that of the 536 compounds screened, six of them may have the potential to regulate the expression of identified targets and thus revive the MMR function preventing genomic instability. These results reveal that there may be potential plant derived biomolecules that may have anticancer properties against the tumors driven by deregulated MMR-pathways.
format	article
author	Priyanjali Bhattacharya Trupti N. Patel
author_facet	Priyanjali Bhattacharya Trupti N. Patel
author_sort	Priyanjali Bhattacharya
title	A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach
title_short	A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach
title_full	A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach
title_fullStr	A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach
title_full_unstemmed	A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach
title_sort	study of deregulated mmr pathways and anticancer potential of curcuma derivatives using computational approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1e416b8bc74e4e0295540cfa5f212a9f
work_keys_str_mv	AT priyanjalibhattacharya astudyofderegulatedmmrpathwaysandanticancerpotentialofcurcumaderivativesusingcomputationalapproach AT truptinpatel astudyofderegulatedmmrpathwaysandanticancerpotentialofcurcumaderivativesusingcomputationalapproach AT priyanjalibhattacharya studyofderegulatedmmrpathwaysandanticancerpotentialofcurcumaderivativesusingcomputationalapproach AT truptinpatel studyofderegulatedmmrpathwaysandanticancerpotentialofcurcumaderivativesusingcomputationalapproach
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A study of deregulated MMR pathways and anticancer potential of curcuma derivatives using computational approach

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