Clinical characterization and outcomes of 85 patients with neurosarcoidosis
Abstract To analyze the frequency and clinical phenotype of neurosarcoidosis (NS) in one of the largest nationwide cohorts of patients with sarcoidosis reported from southern Europe. NS was evaluated according to the Diagnostic Criteria for Central Nervous System and Peripheral Nervous System Sarcoi...
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Nature Portfolio
2021
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oai:doaj.org-article:1e44c96df86b41beb3c7a917cfef4cc52021-12-02T14:33:57ZClinical characterization and outcomes of 85 patients with neurosarcoidosis10.1038/s41598-021-92967-62045-2322https://doaj.org/article/1e44c96df86b41beb3c7a917cfef4cc52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92967-6https://doaj.org/toc/2045-2322Abstract To analyze the frequency and clinical phenotype of neurosarcoidosis (NS) in one of the largest nationwide cohorts of patients with sarcoidosis reported from southern Europe. NS was evaluated according to the Diagnostic Criteria for Central Nervous System and Peripheral Nervous System Sarcoidosis recently proposed by Stern et al. Pathologic confirmation of granulomatous disease was used to subclassify NS into definite (confirmation in neurological tissue), probable (confirmation in extraneurological tissue) and possible (no histopathological confirmation of the disease). Of the 1532 patients included in the cohort, 85 (5.5%) fulfilled the Stern criteria for NS (49 women, mean age at diagnosis of NS of 47.6 years, 91% White). These patients developed 103 neurological conditions involving the brain (38%), cranial nerves (36%), the meninges (3%), the spinal cord (10%) and the peripheral nerves (14%); no patient had concomitant central and peripheral nerve involvements. In 59 (69%) patients, neurological involvement preceded or was present at the time of diagnosis of the disease. According to the classification proposed by Stern et al., 11 (13%) were classified as a definite NS, 61 (72%) as a probable NS and the remaining 13 (15%) as a possible NS. In comparison with the systemic phenotype of patients without NS, patients with CNS involvement presented a lower frequency of thoracic involvement (82% vs 93%, q = 0.018), a higher frequency of ocular (27% vs 10%, q < 0.001) and salivary gland (15% vs 4%, q = 0.002) WASOG involvements. In contrast, patients with PNS involvement showed a higher frequency of liver involvement (36% vs 12%, p = 0.02) in comparison with patients without NS. Neurosarcoidosis was identified in 5.5% of patients. CNS involvement prevails significantly over PNS involvement, and both conditions do not overlap in any patient. The systemic phenotype associated to each involvement was clearly differentiated, and can be helpful not only in the early identification of neurological involvement, but also in the systemic evaluation of patients diagnosed with neurosarcoidosis.Manuel Ramos-CasalsRoberto Pérez-AlvarezBelchin KostovRicardo Gómez-de-la-TorreCarlos Feijoo-MassóJoel Chara-CervantesBlanca PinillaAndrés González-GarcíaJosé-Salvador Garcia-MorilloMiguel López-DuplaBegoña De-EscalanteJavier RascónPatricia Perez-GuerreroMariona BonetGracia Cruz-CaparrósAna AlguacilJosé-Luis CallejasEva CalvoCristina SolerAngel RoblesBorja de Miguel-CampoPedro Oliva-NacarinoJorge Estela-HerreroLucio PallarésPilar Brito-ZerónYolanda Blancothe SarcoGEAS-SEMI RegistryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Manuel Ramos-Casals Roberto Pérez-Alvarez Belchin Kostov Ricardo Gómez-de-la-Torre Carlos Feijoo-Massó Joel Chara-Cervantes Blanca Pinilla Andrés González-García José-Salvador Garcia-Morillo Miguel López-Dupla Begoña De-Escalante Javier Rascón Patricia Perez-Guerrero Mariona Bonet Gracia Cruz-Caparrós Ana Alguacil José-Luis Callejas Eva Calvo Cristina Soler Angel Robles Borja de Miguel-Campo Pedro Oliva-Nacarino Jorge Estela-Herrero Lucio Pallarés Pilar Brito-Zerón Yolanda Blanco the SarcoGEAS-SEMI Registry Clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| description |
Abstract To analyze the frequency and clinical phenotype of neurosarcoidosis (NS) in one of the largest nationwide cohorts of patients with sarcoidosis reported from southern Europe. NS was evaluated according to the Diagnostic Criteria for Central Nervous System and Peripheral Nervous System Sarcoidosis recently proposed by Stern et al. Pathologic confirmation of granulomatous disease was used to subclassify NS into definite (confirmation in neurological tissue), probable (confirmation in extraneurological tissue) and possible (no histopathological confirmation of the disease). Of the 1532 patients included in the cohort, 85 (5.5%) fulfilled the Stern criteria for NS (49 women, mean age at diagnosis of NS of 47.6 years, 91% White). These patients developed 103 neurological conditions involving the brain (38%), cranial nerves (36%), the meninges (3%), the spinal cord (10%) and the peripheral nerves (14%); no patient had concomitant central and peripheral nerve involvements. In 59 (69%) patients, neurological involvement preceded or was present at the time of diagnosis of the disease. According to the classification proposed by Stern et al., 11 (13%) were classified as a definite NS, 61 (72%) as a probable NS and the remaining 13 (15%) as a possible NS. In comparison with the systemic phenotype of patients without NS, patients with CNS involvement presented a lower frequency of thoracic involvement (82% vs 93%, q = 0.018), a higher frequency of ocular (27% vs 10%, q < 0.001) and salivary gland (15% vs 4%, q = 0.002) WASOG involvements. In contrast, patients with PNS involvement showed a higher frequency of liver involvement (36% vs 12%, p = 0.02) in comparison with patients without NS. Neurosarcoidosis was identified in 5.5% of patients. CNS involvement prevails significantly over PNS involvement, and both conditions do not overlap in any patient. The systemic phenotype associated to each involvement was clearly differentiated, and can be helpful not only in the early identification of neurological involvement, but also in the systemic evaluation of patients diagnosed with neurosarcoidosis. |
| format |
article |
| author |
Manuel Ramos-Casals Roberto Pérez-Alvarez Belchin Kostov Ricardo Gómez-de-la-Torre Carlos Feijoo-Massó Joel Chara-Cervantes Blanca Pinilla Andrés González-García José-Salvador Garcia-Morillo Miguel López-Dupla Begoña De-Escalante Javier Rascón Patricia Perez-Guerrero Mariona Bonet Gracia Cruz-Caparrós Ana Alguacil José-Luis Callejas Eva Calvo Cristina Soler Angel Robles Borja de Miguel-Campo Pedro Oliva-Nacarino Jorge Estela-Herrero Lucio Pallarés Pilar Brito-Zerón Yolanda Blanco the SarcoGEAS-SEMI Registry |
| author_facet |
Manuel Ramos-Casals Roberto Pérez-Alvarez Belchin Kostov Ricardo Gómez-de-la-Torre Carlos Feijoo-Massó Joel Chara-Cervantes Blanca Pinilla Andrés González-García José-Salvador Garcia-Morillo Miguel López-Dupla Begoña De-Escalante Javier Rascón Patricia Perez-Guerrero Mariona Bonet Gracia Cruz-Caparrós Ana Alguacil José-Luis Callejas Eva Calvo Cristina Soler Angel Robles Borja de Miguel-Campo Pedro Oliva-Nacarino Jorge Estela-Herrero Lucio Pallarés Pilar Brito-Zerón Yolanda Blanco the SarcoGEAS-SEMI Registry |
| author_sort |
Manuel Ramos-Casals |
| title |
Clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| title_short |
Clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| title_full |
Clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| title_fullStr |
Clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| title_full_unstemmed |
Clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| title_sort |
clinical characterization and outcomes of 85 patients with neurosarcoidosis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1e44c96df86b41beb3c7a917cfef4cc5 |
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