A new test for autism spectrum disorder: Metabolic data from different cell types

Experiments employing the Phenotype Mammalian Microarray (PM-M) technology were performed on lymphoblastoid cell lines (LCLs) from individuals with autism spectrum disorder (ASD) and age-matched controls. We used the custom-made PM-M plate designed to assess differential utilization of the amino aci...

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Autores principales:	Sujata Srikanth, Lauren Cascio, Rini Pauly, Kelly Jones, Skylar Sorrow, Rossana Cubillan, Chin-Fu Chen, Cindy D. Skinner, Kevin Champaigne, Roger E. Stevenson, Charles E. Schwartz, Luigi Boccuto
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Autism spectrum disorder (ASD) Tryptophan Metabolism Diagnostic test Screening test Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/1e46527825824faaabfb3f47fd12c4dc
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spelling	oai:doaj.org-article:1e46527825824faaabfb3f47fd12c4dc2021-11-28T04:33:20ZA new test for autism spectrum disorder: Metabolic data from different cell types2352-340910.1016/j.dib.2021.107598https://doaj.org/article/1e46527825824faaabfb3f47fd12c4dc2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352340921008738https://doaj.org/toc/2352-3409Experiments employing the Phenotype Mammalian Microarray (PM-M) technology were performed on lymphoblastoid cell lines (LCLs) from individuals with autism spectrum disorder (ASD) and age-matched controls. We used the custom-made PM-M plate designed to assess differential utilization of the amino acid tryptophan. Multiple parameters such as the sample size, incubation time, and cell concentration have been tested, leading to optimized protocols and minimized background noise by variable selection while controlling for false discoveries. The assay generated data based on the production of nicotinamide adenine dinucleotide (NADH) in the presence of different compounds containing tryptophan and showed clear differences between ASD and control samples.Sujata SrikanthLauren CascioRini PaulyKelly JonesSkylar SorrowRossana CubillanChin-Fu ChenCindy D. SkinnerKevin ChampaigneRoger E. StevensonCharles E. SchwartzLuigi BoccutoElsevierarticleAutism spectrum disorder (ASD)TryptophanMetabolismDiagnostic testScreening testComputer applications to medicine. Medical informaticsR858-859.7Science (General)Q1-390ENData in Brief, Vol 39, Iss , Pp 107598- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autism spectrum disorder (ASD) Tryptophan Metabolism Diagnostic test Screening test Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
spellingShingle	Autism spectrum disorder (ASD) Tryptophan Metabolism Diagnostic test Screening test Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390 Sujata Srikanth Lauren Cascio Rini Pauly Kelly Jones Skylar Sorrow Rossana Cubillan Chin-Fu Chen Cindy D. Skinner Kevin Champaigne Roger E. Stevenson Charles E. Schwartz Luigi Boccuto A new test for autism spectrum disorder: Metabolic data from different cell types
description	Experiments employing the Phenotype Mammalian Microarray (PM-M) technology were performed on lymphoblastoid cell lines (LCLs) from individuals with autism spectrum disorder (ASD) and age-matched controls. We used the custom-made PM-M plate designed to assess differential utilization of the amino acid tryptophan. Multiple parameters such as the sample size, incubation time, and cell concentration have been tested, leading to optimized protocols and minimized background noise by variable selection while controlling for false discoveries. The assay generated data based on the production of nicotinamide adenine dinucleotide (NADH) in the presence of different compounds containing tryptophan and showed clear differences between ASD and control samples.
format	article
author	Sujata Srikanth Lauren Cascio Rini Pauly Kelly Jones Skylar Sorrow Rossana Cubillan Chin-Fu Chen Cindy D. Skinner Kevin Champaigne Roger E. Stevenson Charles E. Schwartz Luigi Boccuto
author_facet	Sujata Srikanth Lauren Cascio Rini Pauly Kelly Jones Skylar Sorrow Rossana Cubillan Chin-Fu Chen Cindy D. Skinner Kevin Champaigne Roger E. Stevenson Charles E. Schwartz Luigi Boccuto
author_sort	Sujata Srikanth
title	A new test for autism spectrum disorder: Metabolic data from different cell types
title_short	A new test for autism spectrum disorder: Metabolic data from different cell types
title_full	A new test for autism spectrum disorder: Metabolic data from different cell types
title_fullStr	A new test for autism spectrum disorder: Metabolic data from different cell types
title_full_unstemmed	A new test for autism spectrum disorder: Metabolic data from different cell types
title_sort	new test for autism spectrum disorder: metabolic data from different cell types
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1e46527825824faaabfb3f47fd12c4dc
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A new test for autism spectrum disorder: Metabolic data from different cell types

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