Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country

Objectives Colorectal cancer (CRC) is the second leading cause of cancer death in the world, with survival correlated with the extension of the disease at diagnosis. In many low-/middle-income countries, the incidence of CRC is increasing rapidly, while decreasing rates are observed in high-income c...

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Autores principales:	Ricella Maria Souza da Silva, Polyana Maria Cruz Collaço, Karin S. Cunha, Eliane Pedra Dias
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Revinter Publicações Ltda. 2021
Materias:	colorectal cancer pathological features neoplasm staging advanced disease Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/1e4a58738f3045239749abe6e5d78647
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spelling	oai:doaj.org-article:1e4a58738f3045239749abe6e5d786472021-11-18T23:52:52ZDiagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country2237-93632317-642310.1055/s-0041-1736517https://doaj.org/article/1e4a58738f3045239749abe6e5d786472021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1736517https://doaj.org/toc/2237-9363https://doaj.org/toc/2317-6423Objectives Colorectal cancer (CRC) is the second leading cause of cancer death in the world, with survival correlated with the extension of the disease at diagnosis. In many low-/middle-income countries, the incidence of CRC is increasing rapidly, while decreasing rates are observed in high-income countries. We evaluated the anatomopathological profile of 390 patients diagnosed with CRC who underwent surgical resection, over a six-year period, in the state of Paraíba, northeastern Brazil. Results Adenocarcinomas accounted for 98% of the cases of primary colorectal tumors, and 53.8% occurred in female patients. The average age of the sample was 63.5 years, with 81.8% of individuals older than 50 years of age and 6.4% under 40 years of age. The most frequent location was the distal colon; pT3 status was found in 71% of patients, and pT4 status, in 14.4%. Angiolymphatic and lymph-node involvements were found in 48.7% and 46.9% of the cases respectively. Distant metastasis was observed in 9.2% of the patients. Advanced disease was diagnosed in almost half of the patients (48.1%). The women in the sample had poorly-differentiated adenocarcinomas (p = 0.043). Patients under 60 years of age had a higher rate of lymph-node metastasis (p = 0.044). Tumor budding was present in 27.2% of the cases, and it was associated with the female gender, the mucinous histological type, and the depth of invasion (pT3 and pT4). Conclusions We conclude that the diagnosis of advanced disease in CRC is still a reality, with a high occurrence of aggressive prognostic factors, which results in a worse prognosis.Ricella Maria Souza da SilvaPolyana Maria Cruz CollaçoKarin S. CunhaEliane Pedra DiasThieme Revinter Publicações Ltda.articlecolorectal cancerpathological featuresneoplasm stagingadvanced diseaseDiseases of the digestive system. GastroenterologyRC799-869ENJournal of Coloproctology (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer pathological features neoplasm staging advanced disease Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	colorectal cancer pathological features neoplasm staging advanced disease Diseases of the digestive system. Gastroenterology RC799-869 Ricella Maria Souza da Silva Polyana Maria Cruz Collaço Karin S. Cunha Eliane Pedra Dias Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
description	Objectives Colorectal cancer (CRC) is the second leading cause of cancer death in the world, with survival correlated with the extension of the disease at diagnosis. In many low-/middle-income countries, the incidence of CRC is increasing rapidly, while decreasing rates are observed in high-income countries. We evaluated the anatomopathological profile of 390 patients diagnosed with CRC who underwent surgical resection, over a six-year period, in the state of Paraíba, northeastern Brazil. Results Adenocarcinomas accounted for 98% of the cases of primary colorectal tumors, and 53.8% occurred in female patients. The average age of the sample was 63.5 years, with 81.8% of individuals older than 50 years of age and 6.4% under 40 years of age. The most frequent location was the distal colon; pT3 status was found in 71% of patients, and pT4 status, in 14.4%. Angiolymphatic and lymph-node involvements were found in 48.7% and 46.9% of the cases respectively. Distant metastasis was observed in 9.2% of the patients. Advanced disease was diagnosed in almost half of the patients (48.1%). The women in the sample had poorly-differentiated adenocarcinomas (p = 0.043). Patients under 60 years of age had a higher rate of lymph-node metastasis (p = 0.044). Tumor budding was present in 27.2% of the cases, and it was associated with the female gender, the mucinous histological type, and the depth of invasion (pT3 and pT4). Conclusions We conclude that the diagnosis of advanced disease in CRC is still a reality, with a high occurrence of aggressive prognostic factors, which results in a worse prognosis.
format	article
author	Ricella Maria Souza da Silva Polyana Maria Cruz Collaço Karin S. Cunha Eliane Pedra Dias
author_facet	Ricella Maria Souza da Silva Polyana Maria Cruz Collaço Karin S. Cunha Eliane Pedra Dias
author_sort	Ricella Maria Souza da Silva
title	Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
title_short	Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
title_full	Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
title_fullStr	Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
title_full_unstemmed	Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
title_sort	diagnosis of advanced disease in cases of colorectal cancer in a developing country
publisher	Thieme Revinter Publicações Ltda.
publishDate	2021
url	https://doaj.org/article/1e4a58738f3045239749abe6e5d78647
work_keys_str_mv	AT ricellamariasouzadasilva diagnosisofadvanceddiseaseincasesofcolorectalcancerinadevelopingcountry AT polyanamariacruzcollaco diagnosisofadvanceddiseaseincasesofcolorectalcancerinadevelopingcountry AT karinscunha diagnosisofadvanceddiseaseincasesofcolorectalcancerinadevelopingcountry AT elianepedradias diagnosisofadvanceddiseaseincasesofcolorectalcancerinadevelopingcountry
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Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country

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